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Defining the clinical course of multiple sclerosis: The 2013 revisions

Neurology, 2014-07, Vol.83 (3), p.278-286 [Peer Reviewed Journal]

2014 American Academy of Neurology ;2015 INIST-CNRS ;2014 American Academy of Neurology. ;2014 American Academy of Neurology 2014 American Academy of Neurology ;ISSN: 0028-3878 ;EISSN: 1526-632X ;DOI: 10.1212/WNL.0000000000000560 ;PMID: 24871874 ;CODEN: NEURAI

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Title:
Defining the clinical course of multiple sclerosis: The 2013 revisions
Author: Lublin, Fred D ; Reingold, Stephen C ; Cohen, Jeffrey A ; Cutter, Gary R ; Sørensen, Per Soelberg ; Thompson, Alan J ; Wolinsky, Jerry S ; Balcer, Laura J ; Banwell, Brenda ; Barkhof, Frederik ; Bebo, Bruce ; Calabresi, Peter A ; Clanet, Michel ; Comi, Giancarlo ; Fox, Robert J ; Freedman, Mark S ; Goodman, Andrew D ; Inglese, Matilde ; Kappos, Ludwig ; Kieseier, Bernd C ; Lincoln, John A ; Lubetzki, Catherine ; Miller, Aaron E ; Montalban, Xavier ; OʼConnor, Paul W ; Petkau, John ; Pozzilli, Carlo ; Rudick, Richard A ; Sormani, Maria Pia ; Stüve, Olaf ; Waubant, Emmanuelle ; Polman, Chris H
Subjects: Biological and medical sciences ; Clinical Trials as Topic - standards ; Consensus ; Humans ; Immunomodulators ; Medical sciences ; Multiple Sclerosis - classification ; Multiple Sclerosis - physiopathology ; Multiple Sclerosis - therapy ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Pharmacology. Drug treatments ; Societies, Medical - standards ; Views & Reviews
Is Part Of: Neurology, 2014-07, Vol.83 (3), p.278-286
Description: Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment of clinical trials, and treatment decision-making. Standardized descriptions published in 1996 based on a survey of international MS experts provided purely clinical phenotypes based on data and consensus at that time, but imaging and biological correlates were lacking. Increased understanding of MS and its pathology, coupled with general concern that the original descriptors may not adequately reflect more recently identified clinical aspects of the disease, prompted a re-examination of MS disease phenotypes by the International Advisory Committee on Clinical Trials of MS. While imaging and biological markers that might provide objective criteria for separating clinical phenotypes are lacking, we propose refined descriptors that include consideration of disease activity (based on clinical relapse rate and imaging findings) and disease progression. Strategies for future research to better define phenotypes are also outlined.
Publisher: Hagerstown, MD: American Academy of Neurology
Language: English
Identifier: ISSN: 0028-3878
EISSN: 1526-632X
DOI: 10.1212/WNL.0000000000000560
PMID: 24871874
CODEN: NEURAI
Source: MEDLINE
Alma/SFX Local Collection

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Defining the clinical course of multiple sclerosis: The 2013 revisions

2014 American Academy of Neurology ;2015 INIST-CNRS ;2014 American Academy of Neurology. ;2014 American Academy of Neurology 2014 American Academy of Neurology ;ISSN: 0028-3878 ;EISSN: 1526-632X ;DOI: 10.1212/WNL.0000000000000560 ;PMID: 24871874 ;CODEN: NEURAI

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