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Abnormalities in White Matter Microstructure Associated with Chronic Ketamine Use

Neuropsychopharmacology (New York, N.Y.), 2014-01, Vol.39 (2), p.329-338 [Peer Reviewed Journal]

2015 INIST-CNRS ;Copyright Nature Publishing Group Jan 2014 ;Copyright © 2014 American College of Neuropsychopharmacology 2014 American College of Neuropsychopharmacology ;ISSN: 0893-133X ;EISSN: 1740-634X ;DOI: 10.1038/npp.2013.195 ;PMID: 23929545 ;CODEN: NEROEW

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Title:
Abnormalities in White Matter Microstructure Associated with Chronic Ketamine Use
Author: ROBERTS, R. Edward ; CURRAN, H. Valerie ; FRISTON, Karl J ; MORGAN, Celia J. A
Subjects: Adult ; Adult and adolescent clinical studies ; Antidepressants ; Biological and medical sciences ; Brain Chemistry - drug effects ; Brain Chemistry - physiology ; Chronic Disease ; Diffusion Tensor Imaging - methods ; Female ; Humans ; Ketamine - administration & dosage ; Ketamine - adverse effects ; Male ; Medical sciences ; Middle Aged ; Nerve Fibers, Myelinated - drug effects ; Nerve Fibers, Myelinated - metabolism ; Nerve Fibers, Myelinated - pathology ; Original ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Substance-Related Disorders - metabolism ; Substance-Related Disorders - pathology ; Young Adult
Is Part Of: Neuropsychopharmacology (New York, N.Y.), 2014-01, Vol.39 (2), p.329-338
Description: Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist that has been found to induce schizophrenia-type symptoms in humans and is a potent and fast-acting antidepressant. It is also a relatively widespread drug of abuse, particularly in China and the UK. Acute administration has been well characterized, but the effect of extended periods of ketamine use-on brain structure in humans-remains poorly understood. We measured indices of white matter microstructural integrity and connectivity in the brain of 16 ketamine users and 16 poly-drug-using controls, and we used probabilistic tractography to quantify changes in corticosubcortical connectivity associated with ketamine use. We found a reduction in the axial diffusivity profile of white matter in a right hemisphere network of white matter regions in ketamine users compared with controls. Within the ketamine-user group, we found a significant positive association between the connectivity profile between the caudate nucleus and the lateral prefrontal cortex and dissociative experiences. These findings suggest that chronic ketamine use may be associated with widespread disruption of white matter integrity, and white matter pathways between subcortical and prefrontal cortical areas may in part predict individual differences in dissociative experiences due to ketamine use.
Publisher: Basingstoke: Nature Publishing Group
Language: English
Identifier: ISSN: 0893-133X
EISSN: 1740-634X
DOI: 10.1038/npp.2013.195
PMID: 23929545
CODEN: NEROEW
Source: ProQuest One Psychology
GFMER Free Medical Journals
MEDLINE
PubMed Central
ProQuest Central

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Abnormalities in White Matter Microstructure Associated with Chronic Ketamine Use

2015 INIST-CNRS ;Copyright Nature Publishing Group Jan 2014 ;Copyright © 2014 American College of Neuropsychopharmacology 2014 American College of Neuropsychopharmacology ;ISSN: 0893-133X ;EISSN: 1740-634X ;DOI: 10.1038/npp.2013.195 ;PMID: 23929545 ;CODEN: NEROEW

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