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Therapeutic use of traditional Chinese herbal medications for chronic kidney diseases

Kidney international, 2013-12, Vol.84 (6), p.1108-1118 [Peer Reviewed Journal]

2013 International Society of Nephrology ;Copyright Nature Publishing Group Dec 2013 ;ISSN: 0085-2538 ;EISSN: 1523-1755 ;DOI: 10.1038/ki.2013.276 ;PMID: 23868014

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  • Title:
    Therapeutic use of traditional Chinese herbal medications for chronic kidney diseases
  • Author: Zhong, Yifei ; Deng, Yueyi ; Chen, Yiping ; Chuang, Peter Y. ; Cijiang He, John
  • Subjects: alternative medicine ; Animals ; Chinese herb medications ; drug discovery ; Drugs, Chinese Herbal - adverse effects ; Drugs, Chinese Herbal - therapeutic use ; Humans ; kidney disease ; Medicine, Chinese Traditional ; Renal Insufficiency, Chronic - diagnosis ; Renal Insufficiency, Chronic - drug therapy ; toxicity ; Treatment Outcome
  • Is Part Of: Kidney international, 2013-12, Vol.84 (6), p.1108-1118
  • Description: Traditional Chinese herbal medications (TCHMs) are frequently used in conjunction with western pharmacotherapy for treatment of chronic kidney diseases (CKD) in China and many other Asian countries. The practice of traditional Chinese medicine is guided by cumulative empiric experience. Recent in vitro and animal studies have confirmed the biological activity and therapeutic effects of several TCHMs in CKD. However, the level of evidence supporting TCHMs is limited to small, nonrandomized trials. Due to variations in the prescription pattern of TCHMs and the need for frequent dosage adjustment, which are inherent to the practice of traditional Chinese medicine, it has been challenging to design and implement large randomized clinical trials of TCHMs. Several TCHMs are associated with significant adverse effects, including nephrotoxicity. However, reporting of adverse effects associated with TCHMs has been inadequate. To fully realize the therapeutic use of TCHMs in CKD, we need molecular studies to identify active ingredients of TCHMs and their mechanism of action, rigorous pharmacologic studies to determine the safety and meet regulatory standards required for clinical therapeutic agents, and well-designed clinical trials to provide evidence-based support of their safety and efficacy.
  • Publisher: United States: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 0085-2538
    EISSN: 1523-1755
    DOI: 10.1038/ki.2013.276
    PMID: 23868014
  • Source: MEDLINE
    Alma/SFX Local Collection
    ProQuest Central
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