Language:

1-deoxynojirimycin inhibits glucose absorption and accelerates glucose metabolism in streptozotocin-induced diabetic mice

Scientific reports, 2013-03, Vol.3 (1), p.1377, Article 1377 [Peer Reviewed Journal]

Copyright Nature Publishing Group Mar 2013 ;Copyright © 2013, Macmillan Publishers Limited. All rights reserved 2013 Macmillan Publishers Limited. All rights reserved ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep01377 ;PMID: 23536174

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
1-deoxynojirimycin inhibits glucose absorption and accelerates glucose metabolism in streptozotocin-induced diabetic mice
Author: Li, You-Gui ; Ji, Dong-Feng ; Zhong, Shi ; Lin, Tian-Bao ; Lv, Zhi-Qiang ; Hu, Gui-Yan ; Wang, Xin
Subjects: 1-Deoxynojirimycin - pharmacology ; Animals ; Biological Transport - drug effects ; Blood Glucose - drug effects ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Experimental - metabolism ; Enzyme Inhibitors - pharmacology ; Enzymes ; Gene expression ; Gluconeogenesis ; Gluconeogenesis - drug effects ; Glucose ; Glucose - metabolism ; Glucose tolerance ; Glucose transport ; Glucose Transport Proteins, Facilitative - biosynthesis ; Glucose Transport Proteins, Facilitative - drug effects ; Glucose transporter ; Glucose Transporter Type 2 - biosynthesis ; Glucose Transporter Type 2 - genetics ; Glycolysis ; Glycolysis - drug effects ; Intestinal Absorption - drug effects ; Intestine ; Intestines - drug effects ; Intestines - metabolism ; Intravenous administration ; Male ; Metabolism ; Mice ; Mice, Inbred ICR ; mRNA ; Protein expression ; Proteins ; RNA, Messenger - biosynthesis ; Rodents ; Sodium-Glucose Transporter 1 - biosynthesis ; Sodium-Glucose Transporter 1 - genetics ; Sodium-Potassium-Exchanging ATPase - biosynthesis ; Sodium-Potassium-Exchanging ATPase - genetics ; Streptozocin
Is Part Of: Scientific reports, 2013-03, Vol.3 (1), p.1377, Article 1377
Description: We investigated the role of 1-deoxynojirimycin (DNJ) on glucose absorption and metabolism in normal and diabetic mice. Oral and intravenous glucose tolerance tests and labeled (13)C6-glucose uptake assays suggested that DNJ inhibited intestinal glucose absorption in intestine. We also showed that DNJ down-regulated intestinal SGLT1, Na(+)/K(+)-ATP and GLUT2 mRNA and protein expression. Pretreatment with DNJ (50 mg/kg) increased the activity, mRNA and protein levels of hepatic glycolysis enzymes (GK, PFK, PK, PDE1) and decreased the expression of gluconeogenesis enzymes (PEPCK, G-6-Pase). Assays of protein expression in hepatic cells and in vitro tests with purified enzymes indicated that the increased activity of glucose glycolysis enzymes was resulted from the relative increase in protein expression, rather than from direct enzyme activation. These results suggest that DNJ inhibits intestinal glucose absorption and accelerates hepatic glucose metabolism by directly regulating the expression of proteins involved in glucose transport systems, glycolysis and gluconeogenesis enzymes.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2045-2322
EISSN: 2045-2322
DOI: 10.1038/srep01377
PMID: 23536174
Source: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

1-deoxynojirimycin inhibits glucose absorption and accelerates glucose metabolism in streptozotocin-induced diabetic mice

Copyright Nature Publishing Group Mar 2013 ;Copyright © 2013, Macmillan Publishers Limited. All rights reserved 2013 Macmillan Publishers Limited. All rights reserved ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep01377 ;PMID: 23536174

Searching Remote Databases, Please Wait