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DNA replication fading as proliferating cells advance in their commitment to terminal differentiation

Scientific reports, 2012, Vol.2 (1), p.279-279, Article 279 [Peer Reviewed Journal]

Copyright Nature Publishing Group Feb 2012 ;Attribution - NonCommercial - ShareAlike ;Copyright © 2012, Macmillan Publishers Limited. All rights reserved 2012 Macmillan Publishers Limited. All rights reserved ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep00279 ;PMID: 22359734

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Title:
DNA replication fading as proliferating cells advance in their commitment to terminal differentiation
Author: Estefanía, Monturus Ma ; Ganier, Olivier ; Hernández, Pablo ; Schvartzman, Jorge B ; Mechali, Marcel ; Krimer, Dora B
Subjects: Animals ; Base Sequence ; Cell Differentiation ; Cell Line, Tumor ; Cell Proliferation ; Chromatin ; Deoxyribonucleic acid ; DNA ; DNA biosynthesis ; DNA Primers ; DNA Replication ; Erythroleukemia ; Flow Cytometry ; Fluorescent Antibody Technique, Indirect ; Gene expression ; Genetics ; Genomes ; Life Sciences ; Mice ; Replication
Is Part Of: Scientific reports, 2012, Vol.2 (1), p.279-279, Article 279
Description: Terminal differentiation is the process by which cycling cells stop proliferating to start new specific functions. It involves dramatic changes in chromatin organization as well as gene expression. In the present report we used cell flow cytometry and genome wide DNA combing to investigate DNA replication during murine erythroleukemia-induced terminal cell differentiation. The results obtained indicated that the rate of replication fork movement slows down and the inter-origin distance becomes shorter during the precommitment and commitment periods before cells stop proliferating and accumulate in G1. We propose this is a general feature caused by the progressive heterochromatinization that characterizes terminal cell differentiation.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2045-2322
EISSN: 2045-2322
DOI: 10.1038/srep00279
PMID: 22359734
Source: Hyper Article en Ligne (HAL) (Open Access)
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DNA replication fading as proliferating cells advance in their commitment to terminal differentiation

Copyright Nature Publishing Group Feb 2012 ;Attribution - NonCommercial - ShareAlike ;Copyright © 2012, Macmillan Publishers Limited. All rights reserved 2012 Macmillan Publishers Limited. All rights reserved ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep00279 ;PMID: 22359734

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