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High intake of saturated fat, but not polyunsaturated fat, improves survival in heart failure despite persistent mitochondrial defects

Cardiovascular research, 2012-01, Vol.93 (1), p.24-32 [Peer Reviewed Journal]

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011. For permissions please email: journals.permissions@oup.com. 2011 ;2015 INIST-CNRS ;ISSN: 0008-6363 ;EISSN: 1755-3245 ;DOI: 10.1093/cvr/cvr258 ;PMID: 21960686 ;CODEN: CVREAU

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Title:
High intake of saturated fat, but not polyunsaturated fat, improves survival in heart failure despite persistent mitochondrial defects
Author: Galvao, Tatiana F ; Brown, Bethany H ; Hecker, Peter A ; O'Connell, Kelly A ; O'Shea, Karen M ; Sabbah, Hani N ; Rastogi, Sharad ; Daneault, Caroline ; Des Rosiers, Christine ; Stanley, William C
Subjects: Animals ; Animals, Genetically Modified ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiomyopathy, Dilated - diet therapy ; Cardiomyopathy, Dilated - genetics ; Cardiomyopathy, Dilated - metabolism ; Cardiomyopathy, Dilated - pathology ; Cricetinae ; Diet, High-Fat ; Dietary Fats - administration & dosage ; Dietary Fats, Unsaturated - administration & dosage ; Fatty Acids - metabolism ; Heart ; Heart Failure - diet therapy ; Heart Failure - genetics ; Heart Failure - metabolism ; Heart Failure - pathology ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Male ; Medical sciences ; Metabolic diseases ; Mitochondria, Heart - metabolism ; Mitochondria, Heart - pathology ; Myocarditis. Cardiomyopathies ; Obesity ; Original ; Phospholipids - metabolism ; Sarcoglycans - deficiency ; Sarcoglycans - genetics
Is Part Of: Cardiovascular research, 2012-01, Vol.93 (1), p.24-32
Description: Aims The impact of a high-fat diet on the failing heart is unclear, and the differences between polyunsaturated fatty acids (PUFA) and saturated fat have not been assessed. Here, we compared a standard low-fat diet to high-fat diets enriched with either saturated fat (palmitate and stearate) or PUFA (linoleic and α-linolenic acids) in hamsters with genetic cardiomyopathy. Methods and results Male δ-sarcoglycan null Bio TO2 hamsters were fed a standard low-fat diet (12% energy from fat), or high-fat diets (45% fat) comprised of either saturated fat or PUFA. The median survival was increased by the high saturated fat diet (P< 0.01; 278 days with standard diet and 361 days with high saturated fat)), but not with high PUFA (260 days) (n = 30-35/group). Body mass was modestly elevated (∼10%) in both high fat groups. Subgroups evaluated after 24 weeks had similar left ventricular chamber size, function, and mass. Mitochondrial oxidative enzyme activity and the yield of interfibrillar mitochondria (IFM) were decreased to a similar extent in all TO2 groups compared with normal F1B hamsters. Ca2+-induced mitochondrial permeability transition pore opening was enhanced in IFM in all TO2 groups compared with F1B hamsters, but to a significantly greater extent in those fed the high PUFA diet compared with the standard or high saturated fat diet. Conclusion These results show that a high intake of saturated fat improves survival in heart failure compared with a high PUFA diet or low-fat diet, despite persistent mitochondrial defects.
Publisher: Oxford: Oxford University Press
Language: English
Identifier: ISSN: 0008-6363
EISSN: 1755-3245
DOI: 10.1093/cvr/cvr258
PMID: 21960686
CODEN: CVREAU
Source: Geneva Foundation Free Medical Journals at publisher websites
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High intake of saturated fat, but not polyunsaturated fat, improves survival in heart failure despite persistent mitochondrial defects

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011. For permissions please email: journals.permissions@oup.com. 2011 ;2015 INIST-CNRS ;ISSN: 0008-6363 ;EISSN: 1755-3245 ;DOI: 10.1093/cvr/cvr258 ;PMID: 21960686 ;CODEN: CVREAU

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