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Conserved properties of dendritic trees in four cortical interneuron subtypes

Scientific reports, 2011-09, Vol.1, p.89 [Peer Reviewed Journal]

Copyright Nature Publishing Group Sep 2011 ;Copyright © 2011, Macmillan Publishers Limited. All rights reserved 2011 Macmillan Publishers Limited. All rights reserved ;EISSN: 2045-2322 ;DOI: 10.1038/srep00089 ;PMID: 22355608

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Title:
Conserved properties of dendritic trees in four cortical interneuron subtypes
Author: Kubota, Yoshiyuki ; Karube, Fuyuki ; Nomura, Masaki ; Gulledge, Allan T ; Mochizuki, Atsushi ; Schertel, Andreas ; Kawaguchi, Yasuo
Subjects: Animals ; Cerebral Cortex - cytology ; Dendrites ; Dendritic branching ; Depolarization ; Electron microscopy ; Excitability ; Immunohistochemistry ; Integration ; Interneurons ; Interneurons - cytology ; Interneurons - ultrastructure ; Mathematical models ; Microscopy ; Microscopy, Electron, Scanning ; Microtubules ; Morphology ; Neurons ; Neurosciences ; Physiology ; Rats ; Rats, Wistar ; Science
Is Part Of: Scientific reports, 2011-09, Vol.1, p.89
Description: Dendritic trees influence synaptic integration and neuronal excitability, yet appear to develop in rather arbitrary patterns. Using electron microscopy and serial reconstructions, we analyzed the dendritic trees of four morphologically distinct neocortical interneuron subtypes to reveal two underlying organizational principles common to all. First, cross-sectional areas at any given point within a dendrite were proportional to the summed length of all dendritic segments distal to that point. Consistent with this observation, total cross-sectional area was almost perfectly conserved at bifurcation points. Second, dendritic cross-sections became progressively more elliptical at more proximal, larger diameter, dendritic locations. Finally, computer simulations revealed that these conserved morphological features limit distance dependent filtering of somatic EPSPs and facilitate distribution of somatic depolarization into all dendritic compartments. Because these features were shared by all interneurons studied, they may represent common organizational principles underlying the otherwise diverse morphology of dendritic trees.
Publisher: England: Nature Publishing Group
Language: English
Identifier: EISSN: 2045-2322
DOI: 10.1038/srep00089
PMID: 22355608
Source: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Conserved properties of dendritic trees in four cortical interneuron subtypes

Copyright Nature Publishing Group Sep 2011 ;Copyright © 2011, Macmillan Publishers Limited. All rights reserved 2011 Macmillan Publishers Limited. All rights reserved ;EISSN: 2045-2322 ;DOI: 10.1038/srep00089 ;PMID: 22355608

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