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Comparing bivalent and quadrivalent human papillomavirus vaccines: economic evaluation based on transmission model

BMJ, 2011-09, Vol.343 (7825), p.677-677 [Peer Reviewed Journal]

Jit et al 2011 ;BMJ Publishing Group Ltd 2011 ;Copyright: 2011 © Jit et al 2011 ;Jit et al 2011 2011 Jit et al ;ISSN: 0959-8138 ;ISSN: 0959-8146 ;EISSN: 1468-5833 ;EISSN: 1756-1833 ;DOI: 10.1136/bmj.d5775 ;PMID: 21951758 ;CODEN: BMJOAE

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Title:
Comparing bivalent and quadrivalent human papillomavirus vaccines: economic evaluation based on transmission model
Author: Jit, Mark ; Chapman, Ruth ; Hughes, Owain ; Choi, Yoon Hong
Subjects: Adolescent ; Adult ; Age ; Aged ; Anogenital ; Cancer ; Cervical cancer ; Child ; Community health care ; Condylomata Acuminata - economics ; Condylomata Acuminata - prevention & control ; Cost analysis ; Cost effectiveness analysis ; Cost efficiency ; Cost of quality ; Cost-Benefit Analysis ; Dermatology ; Disease ; Disease transmission ; Dosage ; Economic models ; Economics ; Effectiveness ; Female ; Health care costs ; Health Economics ; Health Policy ; Health Service Research ; Human papillomavirus ; Human papillomavirus 11 ; Human papillomavirus 6 ; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 ; Humans ; Immune response ; Immunization ; Immunogenicity ; Immunology (Including Allergy) ; Infections ; Infectious Diseases ; Male ; Medical research ; Medical screening ; Middle Aged ; Models, Theoretical ; Papillomavirus Infections - economics ; Papillomavirus Infections - prevention & control ; Papillomavirus Infections - transmission ; Papillomavirus vaccines ; Papillomavirus Vaccines - economics ; Papillomavirus Vaccines - immunology ; Quality of life ; Sexual Health ; Vaccination ; Vaccines ; Warts ; Young Adult
Is Part Of: BMJ, 2011-09, Vol.343 (7825), p.677-677
Description: Objectives To compare the effect and cost effectiveness of bivalent and quadrivalent human papillomavirus (HPV) vaccination, taking into account differences in licensure indications, protection against non-vaccine type disease, protection against disease related to HPV types 6 and 11, and reported long term immunogenicity.Design A model of HPV transmission and disease previously used to inform UK vaccination policy, updated with recent evidence and expanded to include scenarios where the two vaccines differ in duration of protection, cross protection, and end points prevented. Setting United Kingdom.Population Males and females aged 12–75 years.Main outcome measure Incremental cost effectiveness ratios for both vaccines and additional cost per dose for the quadrivalent vaccine to be equally cost effective as the bivalent vaccine.Results The bivalent vaccine needs to be cheaper than the quadrivalent vaccine to be equally cost effective, mainly because of its lack of protection against anogenital warts. The price difference per dose ranges from a median of £19 (interquartile range £12–£27) to £35 (£27–£44) across scenarios about vaccine duration, cross protection, and end points prevented (assuming one quality adjusted life year (QALY) is valued at £30 000 and both vaccines can prevent all types of HPV related cancers).Conclusions The quadrivalent vaccine may have an advantage over the bivalent vaccine in reducing healthcare costs and QALYs lost. The bivalent vaccine may have an advantage in preventing death due to cancer. However, considerable uncertainty remains about the differential benefit of the two vaccines.
Publisher: England: British Medical Journal Publishing Group
Language: English
Identifier: ISSN: 0959-8138
ISSN: 0959-8146
EISSN: 1468-5833
EISSN: 1756-1833
DOI: 10.1136/bmj.d5775
PMID: 21951758
CODEN: BMJOAE
Source: BMJ Open Access Journals
MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Comparing bivalent and quadrivalent human papillomavirus vaccines: economic evaluation based on transmission model

Jit et al 2011 ;BMJ Publishing Group Ltd 2011 ;Copyright: 2011 © Jit et al 2011 ;Jit et al 2011 2011 Jit et al ;ISSN: 0959-8138 ;ISSN: 0959-8146 ;EISSN: 1468-5833 ;EISSN: 1756-1833 ;DOI: 10.1136/bmj.d5775 ;PMID: 21951758 ;CODEN: BMJOAE

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