Language:

The Ca2+ pumps of the endoplasmic reticulum and Golgi apparatus

Cold Spring Harbor perspectives in biology, 2011-05, Vol.3 (5), p.a004184-a004184 [Peer Reviewed Journal]

Copyright © 2011 Cold Spring Harbor Laboratory Press; all rights reserved 2011 ;ISSN: 1943-0264 ;EISSN: 1943-0264 ;DOI: 10.1101/cshperspect.a004184 ;PMID: 21441596

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
The Ca2+ pumps of the endoplasmic reticulum and Golgi apparatus
Author: Vandecaetsbeek, Ilse ; Vangheluwe, Peter ; Raeymaekers, Luc ; Wuytack, Frank ; Vanoevelen, Jo
Subjects: Animals ; Calcium - metabolism ; Calcium Signaling ; Calcium-Transporting ATPases - chemistry ; Calcium-Transporting ATPases - metabolism ; Calcium-Transporting ATPases - physiology ; Developmental Disabilities - genetics ; Developmental Disabilities - metabolism ; Endoplasmic Reticulum - chemistry ; Endoplasmic Reticulum - metabolism ; Gene Expression Regulation ; Golgi Apparatus - chemistry ; Golgi Apparatus - metabolism ; Humans ; Pemphigus, Benign Familial - genetics ; Pemphigus, Benign Familial - metabolism ; Protein Isoforms - chemistry ; Protein Isoforms - metabolism ; Protein Isoforms - physiology ; Protein Structure, Tertiary ; Sarcoplasmic Reticulum Calcium-Transporting ATPases - chemistry ; Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism ; Sarcoplasmic Reticulum Calcium-Transporting ATPases - physiology
Is Part Of: Cold Spring Harbor perspectives in biology, 2011-05, Vol.3 (5), p.a004184-a004184
Description: The various splice variants of the three SERCA- and the two SPCA-pump genes in higher vertebrates encode P-type ATPases of the P(2A) group found respectively in the membranes of the endoplasmic reticulum and the secretory pathway. Of these, SERCA2b and SPCA1a represent the housekeeping isoforms. The SERCA2b form is characterized by a luminal carboxy terminus imposing a higher affinity for cytosolic Ca(2+) compared to the other SERCAs. This is mediated by intramembrane and luminal interactions of this extension with the pump. Other known affinity modulators like phospholamban and sarcolipin decrease the affinity for Ca(2+). The number of proteins reported to interact with SERCA is rapidly growing. Here, we limit the discussion to those for which the interaction site with the ATPase is specified: HAX-1, calumenin, histidine-rich Ca(2+)-binding protein, and indirectly calreticulin, calnexin, and ERp57. The role of the phylogenetically older and structurally simpler SPCAs as transporters of Ca(2+), but also of Mn(2+), is also addressed.
Publisher: United States: Cold Spring Harbor Laboratory Press
Language: English
Identifier: ISSN: 1943-0264
EISSN: 1943-0264
DOI: 10.1101/cshperspect.a004184
PMID: 21441596
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

The Ca2+ pumps of the endoplasmic reticulum and Golgi apparatus

Copyright © 2011 Cold Spring Harbor Laboratory Press; all rights reserved 2011 ;ISSN: 1943-0264 ;EISSN: 1943-0264 ;DOI: 10.1101/cshperspect.a004184 ;PMID: 21441596

Searching Remote Databases, Please Wait