Language:

Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment

European heart journal, 2011-03, Vol.32 (6), p.670-679 [Peer Reviewed Journal]

2015 INIST-CNRS ;Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: journals.permissions@oxfordjournals.org 2010 ;ISSN: 0195-668X ;EISSN: 1522-9645 ;DOI: 10.1093/eurheartj/ehq426 ;PMID: 21138935

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment
Author: BORLAUG, Barry A ; PAULUS, Walter J
Subjects: Algorithms ; Arrhythmias, Cardiac - etiology ; Biological and medical sciences ; Biomarkers - metabolism ; Cardiology. Vascular system ; Cardiotonic Agents - therapeutic use ; Cardiovascular system ; CCN Intercellular Signaling Proteins - metabolism ; Clinical Trials as Topic ; Collagen - physiology ; Connectin ; Elasticity ; Exercise - physiology ; Exercise Test ; Extracellular Matrix - physiology ; Heart ; Heart Failure - diagnosis ; Heart Failure - etiology ; Heart Failure - therapy ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Humans ; Hypertension - etiology ; Investigative techniques of hemodynamics ; Investigative techniques, diagnostic techniques (general aspects) ; Matrix Metalloproteinases - metabolism ; Medical sciences ; Muscle Proteins - metabolism ; Myocytes, Cardiac - pathology ; Physical Exertion - physiology ; Protein Kinases - metabolism ; Reviews ; Stroke Volume - physiology ; Tissue Inhibitor of Metalloproteinases - metabolism ; Vascular Diseases - etiology ; Vascular Stiffness - physiology ; Ventricular Dysfunction, Left - diagnosis ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - therapy ; Ventricular Remodeling - physiology
Is Part Of: European heart journal, 2011-03, Vol.32 (6), p.670-679
Description: Half of patients with heart failure (HF) have a preserved left ventricular ejection fraction (HFpEF). Morbidity and mortality in HFpEF are similar to values observed in patients with HF and reduced EF, yet no effective treatment has been identified. While early research focused on the importance of diastolic dysfunction in the pathophysiology of HFpEF, recent studies have revealed that multiple non-diastolic abnormalities in cardiovascular function also contribute. Diagnosis of HFpEF is frequently challenging and relies upon careful clinical evaluation, echo-Doppler cardiography, and invasive haemodynamic assessment. In this review, the principal mechanisms, diagnostic approaches, and clinical trials are reviewed, along with a discussion of novel treatment strategies that are currently under investigation or hold promise for the future.
Publisher: Oxford: Oxford University Press
Language: English
Identifier: ISSN: 0195-668X
EISSN: 1522-9645
DOI: 10.1093/eurheartj/ehq426
PMID: 21138935
Source: GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment

2015 INIST-CNRS ;Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: journals.permissions@oxfordjournals.org 2010 ;ISSN: 0195-668X ;EISSN: 1522-9645 ;DOI: 10.1093/eurheartj/ehq426 ;PMID: 21138935

Searching Remote Databases, Please Wait