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Amyloid imaging of Lewy body-associated disorders

Movement disorders, 2010-11, Vol.25 (15), p.2516-2523 [Peer Reviewed Journal]

Copyright © 2010 Movement Disorder Society ;2015 INIST-CNRS ;2010 Movement Disorder Society. ;ISSN: 0885-3185 ;EISSN: 1531-8257 ;DOI: 10.1002/mds.23393 ;PMID: 20922808 ;CODEN: MOVDEA

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Title:
Amyloid imaging of Lewy body-associated disorders
Author: Foster, Erin R. ; Campbell, Meghan C. ; Burack, Michelle A. ; Hartlein, Johanna ; Flores, Hubert P. ; Cairns, Nigel J. ; Hershey, Tamara ; Perlmutter, Joel S.
Subjects: Aged ; Aged, 80 and over ; alpha-Synuclein - metabolism ; Amyloid beta-Peptides - metabolism ; Aniline Compounds ; Biological and medical sciences ; Brain - diagnostic imaging ; Brain - metabolism ; Brain - pathology ; Cognition ; Cognition Disorders - diagnostic imaging ; Cognition Disorders - metabolism ; Cognition Disorders - pathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; dementia with Lewy bodies ; Diagnosis, Differential ; Female ; Humans ; Lewy Bodies - diagnostic imaging ; Lewy Bodies - metabolism ; Lewy Bodies - pathology ; Lewy Body Disease - diagnostic imaging ; Lewy Body Disease - metabolism ; Lewy Body Disease - pathology ; Male ; Medical sciences ; Middle Aged ; Neurology ; Neuropsychological Tests ; Parkinson Disease - diagnostic imaging ; Parkinson Disease - metabolism ; Parkinson Disease - pathology ; Parkinson's disease ; Parkinson's disease with dementia ; PET ; Positron-Emission Tomography - methods ; Severity of Illness Index ; Statistics, Nonparametric ; Thiazoles
Is Part Of: Movement disorders, 2010-11, Vol.25 (15), p.2516-2523
Description: Clinicopathologic studies of Parkinson disease dementia (PDD) and dementia with Lewy bodies (DLB) commonly reveal abnormal β‐amyloid deposition in addition to diffuse Lewy bodies (α‐synuclein aggregates), but the relationship among these neuropathologic features and the development of dementia in these disorders remains uncertain. The purpose of this study was to determine whether amyloid‐β deposition detected by PET imaging with Pittsburgh Compound B (PIB) distinguishes clinical subtypes of Lewy body‐associated disorders. Nine healthy controls, 8 PD with no cognitive impairment, 9 PD with mild cognitive impairment, 6 DLB, and 15 PDD patients underwent [11C]‐PIB positron emission tomography imaging, clinical examination, and cognitive testing. The binding potential (BP) of PIB for predefined regions and the mean cortical BP (MCBP) were calculated for each participant. Annual longitudinal follow‐up and postmortem examinations were performed on a subset of participants. Regional PIB BPs and the proportion of individuals with abnormally elevated MCBP were not significantly different across participant groups. Elevated PIB binding was associated with worse global cognitive impairment in participants with Lewy body disorders but was not associated with any other clinical or neuropsychological features, including earlier onset or faster rate of progression of cognitive impairment. These results suggest that the presence of fibrillar amyloid‐β does not distinguish between clinical subtypes of Lewy body‐associated disorders, although larger numbers are needed to more definitively rule out this association. Amyloid‐β may modify the severity of global cognitive impairment in individuals with Lewy body‐associated dementia. © 2010 Movement Disorder Society
Publisher: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Language: English
Identifier: ISSN: 0885-3185
EISSN: 1531-8257
DOI: 10.1002/mds.23393
PMID: 20922808
CODEN: MOVDEA
Source: MEDLINE
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Amyloid imaging of Lewy body-associated disorders

Copyright © 2010 Movement Disorder Society ;2015 INIST-CNRS ;2010 Movement Disorder Society. ;ISSN: 0885-3185 ;EISSN: 1531-8257 ;DOI: 10.1002/mds.23393 ;PMID: 20922808 ;CODEN: MOVDEA

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