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Diastolic dysfunction in diabetes and the metabolic syndrome: promising potential for diagnosis and prognosis

Diabetologia, 2010-06, Vol.53 (6), p.1033-1045 [Peer Reviewed Journal]

The Author(s) 2010 ;2015 INIST-CNRS ;Springer-Verlag 2010 ;ISSN: 0012-186X ;EISSN: 1432-0428 ;DOI: 10.1007/s00125-010-1682-3 ;PMID: 20349347

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Title:
Diastolic dysfunction in diabetes and the metabolic syndrome: promising potential for diagnosis and prognosis
Author: von Bibra, H ; St John Sutton, M
Subjects: Biological and medical sciences ; cardiovascular diseases ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - physiopathology ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Diastolic dysfunction ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Human Physiology ; Humans ; Internal Medicine ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic Syndrome - physiopathology ; Miscellaneous ; noninsulin-dependent diabetes mellitus ; Other metabolic disorders ; Prognosis ; Review ; Risk Factors ; Tissue Doppler imaging
Is Part Of: Diabetologia, 2010-06, Vol.53 (6), p.1033-1045
Description: Cardiac disease in diabetes mellitus and in the metabolic syndrome consists of both vascular and myocardial abnormalities. The latter are characterised predominantly by diastolic dysfunction, which has been difficult to evaluate in spite of its prevalence. While traditional Doppler echocardiographic parameters enable only semiquantitative assessment of diastolic function and cannot reliably distinguish perturbations in loading conditions from altered diastolic functions, new technologies enable detailed quantification of global and regional diastolic function. The most readily available technique for the quantification of subclinical diastolic dysfunction is tissue Doppler imaging, which has been integrated into routine contemporary clinical practice, whereas cine magnetic resonance imaging (CMR) remains a promising complementary research tool for investigating the molecular mechanisms of the disease. Diastolic function is reported to vary linearly with age in normal persons, decreasing by 0.16 cm/s each year. Diastolic function in diabetes and the metabolic syndrome is determined by cardiovascular risk factors that alter myocardial stiffness and myocardial energy availability/bioenergetics. The latter is corroborated by the improvement in diastolic function with improvement in metabolic control of diabetes by specific medical therapy or lifestyle modification. Accordingly, diastolic dysfunction reflects the structural and metabolic milieu in the myocardium, and may allow targeted therapeutic interventions to modulate cardiac metabolism to prevent heart failure in insulin resistance and diabetes.
Publisher: Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
Language: English
Identifier: ISSN: 0012-186X
EISSN: 1432-0428
DOI: 10.1007/s00125-010-1682-3
PMID: 20349347
Source: SpringerOpen
MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Diastolic dysfunction in diabetes and the metabolic syndrome: promising potential for diagnosis and prognosis

The Author(s) 2010 ;2015 INIST-CNRS ;Springer-Verlag 2010 ;ISSN: 0012-186X ;EISSN: 1432-0428 ;DOI: 10.1007/s00125-010-1682-3 ;PMID: 20349347

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