skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Phenylketonuria: A Scoring System for Brain Magnetic Resonance Imaging

Turkish archives of pediatrics, 2023-09, Vol.58 (5), p.519-526 [Peer Reviewed Journal]

2023 authors 2023 authors ;ISSN: 2757-6256 ;EISSN: 2757-6256 ;DOI: 10.5152/TurkArchPediatr.2023.23081 ;PMID: 37670551

Full text available

Citations Cited by
  • Title:
    Phenylketonuria: A Scoring System for Brain Magnetic Resonance Imaging
  • Author: Bako, Derya ; Çıkı, Kısmet
  • Subjects: Original
  • Is Part Of: Turkish archives of pediatrics, 2023-09, Vol.58 (5), p.519-526
  • Description: OBJECTIVEThe purpose of our study was to devise a new brain Magnetic Resonance Imaging (MRI) scoring system based on the Loes and modified Loes scores in phenylketonuria (PKU) patients. MATERIALS AND METHODSThe brain MRI scans of patients with late diagnosed PKU were evalu- ated retrospectively. Patients' age at diagnosis, age at which diet started, age at MRI, and, blood phenylalanine (Phe) levels at the time point closest to the MRI were recorded. RESULTSEleven patients aged from 3 to 28 years were included in the study. The median MRI involvement score was 17 (interquartile range = 3). The most involved white matter areas were the parietooccipital areas. There was a significant (P = .046) correlation between the blood Phe level at the timepoint closest to the imaging and the MRI involvement score. CONCLUSIONOur study provides insights into the MRI findings and scoring system in PKU patients. We have developed a scoring system based on the widely used Loes and modified Loes scoring systems that can be implemented in clinical practice. Also, our study contributes to the long-forgotten and largely abandoned area-imaging findings in late diagnosed and untreated PKU patients and set the stage for the future research in this field.
  • Publisher: Turkish Pediatrics Association
  • Language: English
  • Identifier: ISSN: 2757-6256
    EISSN: 2757-6256
    DOI: 10.5152/TurkArchPediatr.2023.23081
    PMID: 37670551
  • Source: PubMed Central
    ProQuest Central
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait