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A survival analysis of idiopathic pulmonary fibrosis in the context of antifibrotic therapy in Saudi Arabia

Annals of thoracic medicine, 2023-04, Vol.18 (2), p.79-85 [Peer Reviewed Journal]

Copyright: © 2023 Annals of Thoracic Medicine. ;Copyright: © 2023 Annals of Thoracic Medicine 2023 ;ISSN: 1817-1737 ;EISSN: 1998-3557 ;DOI: 10.4103/atm.atm_264_22 ;PMID: 37323372

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  • Title:
    A survival analysis of idiopathic pulmonary fibrosis in the context of antifibrotic therapy in Saudi Arabia
  • Author: Khan, Mohammed Ayaz ; Ghamdi, Basma Al ; Alhamadi, Mohammed ; Rajendram, Rajkumar ; Alyami, Sami ; Al-Gamedi, Majed ; Al-Harbi, Abdullah ; Al-Jahdali, Hamdan
  • Subjects: Original
  • Is Part Of: Annals of thoracic medicine, 2023-04, Vol.18 (2), p.79-85
  • Description: The prognosis of idiopathic pulmonary fibrosis (IPF) can be predicted by the gender, age, and physiology (GAP) index. However, antifibrotic therapy (i.e., nintedanib and pirfenidone) may improve survival. This study aimed to compare the outcomes of antifibrotic-treated IPF with the survival predicted by the GAP index. A retrospective cohort study was conducted from March 2014 to January 2020. The electronic health-care records of all IPF patients treated with nintedanib or pirfenidone were reviewed. Besides standard demographic and mortality data, the variables required to calculate the GAP index were also extracted. Eighty-one patients (male 55, 68%; age 71.4 ± 10.2 years) with IPF received antifibrotic therapy (nintedanib 44.4%; pirfenidone 55.6%; mean follow-up 35 ± 16.5 months). Cumulative mortality (whole cohort 3 years 12%; 4 years 26%; 5 years 33%) was significantly less than predicted by the GAP index. The survival of antifibrotic-treated IPF is better than predicted by the GAP index. Novel systems for prognostication are required. The survival benefit from pirfenidone and nintedanib seem similar overall.
  • Publisher: India: Wolters Kluwer - Medknow
  • Language: English
  • Identifier: ISSN: 1817-1737
    EISSN: 1998-3557
    DOI: 10.4103/atm.atm_264_22
    PMID: 37323372
  • Source: TestCollectionTL3OpenAccess
    GFMER Free Medical Journals
    PubMed Central
    Medknow Open Access Medical Journals
    ProQuest Central
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