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Curcumin Protects the Rat Liver from CCl4-Caused Injury and Fibrogenesis by Attenuating Oxidative Stress and Suppressing Inflammation

Molecular pharmacology, 2008-02, Vol.73 (2), p.399 [Peer Reviewed Journal]

ISSN: 0026-895X ;EISSN: 1521-0111 ;DOI: 10.1124/mol.107.039818 ;PMID: 18006644

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Title:
Curcumin Protects the Rat Liver from CCl4-Caused Injury and Fibrogenesis by Attenuating Oxidative Stress and Suppressing Inflammation
Author: Fu, Yumei ; Zheng, Shizhong ; Lin, Jianguo ; Ryerse, Jan ; Chen, Anping
Subjects: Animals ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Carbon Tetrachloride Poisoning - metabolism ; Carbon Tetrachloride Poisoning - prevention & control ; Curcumin - pharmacology ; Curcumin - therapeutic use ; Inflammation - metabolism ; Inflammation - pathology ; Inflammation - prevention & control ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Liver Cirrhosis - chemically induced ; Liver Cirrhosis - metabolism ; Liver Cirrhosis - pathology ; Liver Cirrhosis - prevention & control ; Male ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; Rats ; Rats, Sprague-Dawley
Is Part Of: Molecular pharmacology, 2008-02, Vol.73 (2), p.399
Description: We previously demonstrated that curcumin, a polyphenolic antioxidant purified from turmeric, up-regulated peroxisome proliferator-activated receptor (PPAR)-Î³ gene expression and stimulated its signaling, leading to the inhibition of activation of hepatic stellate cells (HSC) in vitro. The current study evaluates the in vivo role of curcumin in protecting the liver against injury and fibrogenesis caused by carbon tetrachloride (CCl 4 ) in rats and further explores the underlying mechanisms. We hypothesize that curcumin might protect the liver from CCl 4 -caused injury and fibrogenesis by attenuating oxidative stress, suppressing inflammation, and inhibiting activation of HSC. This report demonstrates that curcumin significantly protects the liver from injury by reducing the activities of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, and by improving the histological architecture of the liver. In addition, curcumin attenuates oxidative stress by increasing the content of hepatic glutathione, leading to the reduction in the level of lipid hydroperoxide. Curcumin dramatically suppresses inflammation by reducing levels of inflammatory cytokines, including interferon-Î³, tumor necrosis factor-Î±, and interleukin-6. Furthermore, curcumin inhibits HSC activation by elevating the level of PPARÎ³ and reducing the abundance of platelet-derived growth factor, transforming growth factor-Î², their receptors, and type I collagen. This study demonstrates that curcumin protects the rat liver from CCl 4 -caused injury and fibrogenesis by suppressing hepatic inflammation, attenuating hepatic oxidative stress and inhibiting HSC activation. These results confirm and extend our prior in vitro observations and provide novel insights into the mechanisms of curcumin in the protection of the liver. Our results suggest that curcumin might be a therapeutic antifibrotic agent for the treatment of hepatic fibrosis.
Publisher: United States: American Society for Pharmacology and Experimental Therapeutics
Language: English
Identifier: ISSN: 0026-895X
EISSN: 1521-0111
DOI: 10.1124/mol.107.039818
PMID: 18006644
Source: Geneva Foundation Free Medical Journals at publisher websites
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Curcumin Protects the Rat Liver from CCl4-Caused Injury and Fibrogenesis by Attenuating Oxidative Stress and Suppressing Inflammation

ISSN: 0026-895X ;EISSN: 1521-0111 ;DOI: 10.1124/mol.107.039818 ;PMID: 18006644

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