Language:

Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease

Kidney international, 2011-06, Vol.79 (12), p.1370-1378 [Peer Reviewed Journal]

2011 International Society of Nephrology ;2015 INIST-CNRS ;Copyright Nature Publishing Group Jun 2011 ;ISSN: 0085-2538 ;EISSN: 1523-1755 ;DOI: 10.1038/ki.2011.47 ;PMID: 21389978 ;CODEN: KDYIA5

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease
Author: Isakova, Tamara ; Wahl, Patricia ; Vargas, Gabriela S. ; Gutiérrez, Orlando M. ; Scialla, Julia ; Xie, Huiliang ; Appleby, Dina ; Nessel, Lisa ; Bellovich, Keith ; Chen, Jing ; Hamm, Lee ; Gadegbeku, Crystal ; Horwitz, Edward ; Townsend, Raymond R. ; Anderson, Cheryl A.M. ; Lash, James P. ; Hsu, Chi-yuan ; Leonard, Mary B. ; Wolf, Myles ; on behalf of the Chronic Renal Insufficiency Cohort (CRIC) Study Group
Subjects: Aged ; Biological and medical sciences ; Biomarkers - blood ; Biomarkers - urine ; chronic kidney disease ; Female ; FGF23 ; Fibroblast Growth Factors - blood ; Glomerular Filtration Rate ; Humans ; Hyperparathyroidism, Secondary - blood ; Hyperparathyroidism, Secondary - diagnosis ; Hyperparathyroidism, Secondary - etiology ; Hyperparathyroidism, Secondary - physiopathology ; Hyperparathyroidism, Secondary - urine ; Hyperphosphatemia - blood ; Hyperphosphatemia - diagnosis ; Hyperphosphatemia - etiology ; Hyperphosphatemia - physiopathology ; Hyperphosphatemia - urine ; Kidneys ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Parathyroid Hormone - blood ; phosphate ; Phosphates - blood ; Phosphates - urine ; Phosphorus, Dietary - metabolism ; Predictive Value of Tests ; Prospective Studies ; Renal failure ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - diagnosis ; Renal Insufficiency, Chronic - physiopathology ; Renal Insufficiency, Chronic - urine ; Severity of Illness Index ; Time Factors ; United States ; Up-Regulation ; Urinary system involvement in other diseases. Miscellaneous
Is Part Of: Kidney international, 2011-06, Vol.79 (12), p.1370-1378
Description: Fibroblast growth factor 23 (FGF23) regulates phosphorus metabolism and is a strong predictor of mortality in dialysis patients. FGF23 is thought to be an early biomarker of disordered phosphorus metabolism in the initial stages of chronic kidney disease (CKD). We measured FGF23 in baseline samples from 3879 patients in the Chronic Renal Insufficiency Cohort study, which is a diverse cohort of patients with CKD stage 2–4. Mean serum phosphate and median parathyroid hormone (PTH) levels were in the normal range, but median FGF23 was markedly greater than in healthy populations, and increased significantly with decreasing estimated glomerular filtration rate (eGFR). High levels of FGF23, defined as being above 100RU/ml, were more common than secondary hyperparathyroidism and hyperphosphatemia in all strata of eGFR. The threshold of eGFR at which the slope of FGF23 increased was significantly higher than the corresponding threshold for PTH based on non-overlapping 95% confidence intervals. Thus, increased FGF23 is a common manifestation of CKD that develops earlier than increased phosphate or PTH. Hence, FGF23 measurements may be a sensitive early biomarker of disordered phosphorus metabolism in patients with CKD and normal serum phosphate levels.
Publisher: Basingstoke: Elsevier Inc
Language: English
Identifier: ISSN: 0085-2538
EISSN: 1523-1755
DOI: 10.1038/ki.2011.47
PMID: 21389978
CODEN: KDYIA5
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease

2011 International Society of Nephrology ;2015 INIST-CNRS ;Copyright Nature Publishing Group Jun 2011 ;ISSN: 0085-2538 ;EISSN: 1523-1755 ;DOI: 10.1038/ki.2011.47 ;PMID: 21389978 ;CODEN: KDYIA5

Searching Remote Databases, Please Wait