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Effects of the antiserum against a fraction enriched in scrapie-associated fibrils on the scrapie incubation period in mice

MICROBIOLOGY and IMMUNOLOGY, 1988, Vol.32(7), pp.749-753 [Peer Reviewed Journal]

Center for Academic Publications Japan ;owned by Center for Academic Publications Japan (Publisher) ;1989 INIST-CNRS ;ISSN: 0385-5600 ;EISSN: 1348-0421 ;DOI: 10.1111/j.1348-0421.1988.tb01436.x ;PMID: 3143050 ;CODEN: MIIMDV

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Title:
Effects of the antiserum against a fraction enriched in scrapie-associated fibrils on the scrapie incubation period in mice
Author: Ito, M ; Shinagawa, M ; Doi, S ; Sasaki, S ; Isomura, H ; Takahashi, K ; Goto, H ; Sato, G
Subjects: Animals ; Antibodies ; Antibodies, Viral - administration & dosage ; antiserum ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Mice ; Mice, Inbred ICR ; Microbiology ; pathogenicity ; Prions - immunology ; scrapie ; Scrapie - etiology ; Time Factors ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Virology
Is Part Of: MICROBIOLOGY and IMMUNOLOGY, 1988, Vol.32(7), pp.749-753
Description: An antiserum against a fraction enriched for scrapie-associated fibrils (SAF), was examined for its effects on scrapie incubation period by inoculating mice either intraperitoneally or intracerebrally with various dilutions of the serum mixed with scrapie-infected mouse brain homogenate. After intraperitoneal inoculation the mean time of the incubation period increased with increasing concentrations of the antiserum in a statistically significant fashion, when the serum dilutions were made with phosphate-buffered saline. After intracerebral inoculation, however, there were no statistically significant differences between the control group and any of the antiserum-groups. When the antiserum dilutions were made with pre-immune serum, the mice inoculated intraperitoneally also showed no significant differences between the two groups. These results indicate that the specific antibodies to SAF have no effect on the scrapie infectivity.
Publisher: Tokyo: Blackwell Publishing Ltd
Language: English
Identifier: ISSN: 0385-5600
EISSN: 1348-0421
DOI: 10.1111/j.1348-0421.1988.tb01436.x
PMID: 3143050
CODEN: MIIMDV
Source: MEDLINE
Alma/SFX Local Collection
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Effects of the antiserum against a fraction enriched in scrapie-associated fibrils on the scrapie incubation period in mice

Center for Academic Publications Japan ;owned by Center for Academic Publications Japan (Publisher) ;1989 INIST-CNRS ;ISSN: 0385-5600 ;EISSN: 1348-0421 ;DOI: 10.1111/j.1348-0421.1988.tb01436.x ;PMID: 3143050 ;CODEN: MIIMDV

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