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A Host-Targeting Signal in Virulence Proteins Reveals a Secretome in Malarial Infection

Science (American Association for the Advancement of Science), 2004-12, Vol.306 (5703), p.1934-1937 [Peer Reviewed Journal]

Copyright 2004 American Association for the Advancement of Science ;2005 INIST-CNRS ;COPYRIGHT 2004 American Association for the Advancement of Science ;Copyright American Association for the Advancement of Science Dec 10, 2004 ;ISSN: 0036-8075 ;EISSN: 1095-9203 ;DOI: 10.1126/science.1102737 ;PMID: 15591203 ;CODEN: SCIEAS

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Title:
A Host-Targeting Signal in Virulence Proteins Reveals a Secretome in Malarial Infection
Author: Hiller, N. Luisa ; Bhattacharjee, Souvik ; van Ooij, Christiaan ; Liolios, Konstantinos ; Harrison, Travis ; Lopez-Estraño, Carlos ; Haldar, Kasturi
Subjects: Amino Acid Motifs ; Amino Acid Sequence ; Amino acids ; Animals ; Biological and medical sciences ; Brackish ; Computational Biology ; Culicidae ; Cytosol - metabolism ; Erythrocyte membrane ; Erythrocytes ; Erythrocytes - metabolism ; Erythrocytes - parasitology ; Fluorescence ; Freshwater ; Fundamental and applied biological sciences. Psychology ; Genes, Protozoan ; Genomes ; Human protozoal diseases ; Humans ; Infections ; Infectious diseases ; Life cycle. Host-agent relationship. Pathogenesis ; Malaria ; Malaria, Falciparum - parasitology ; Medical sciences ; Membrane Proteins - chemistry ; Membrane Proteins - metabolism ; Molecular Sequence Data ; Parasites ; Parasitic diseases ; Parasitism ; Plasmodium falciparum ; Plasmodium falciparum - genetics ; Plasmodium falciparum - growth & development ; Plasmodium falciparum - metabolism ; Plasmodium falciparum - pathogenicity ; Protein Sorting Signals ; Protein Structure, Tertiary ; Protein Transport ; Proteins ; Protozoa ; Protozoal diseases ; Protozoan Proteins - chemistry ; Protozoan Proteins - genetics ; Protozoan Proteins - metabolism ; Recombinant Fusion Proteins - chemistry ; Recombinant Fusion Proteins - metabolism ; Transgenes ; Vacuoles - metabolism ; Vacuoles - parasitology ; Virulence ; Virulence Factors - chemistry ; Virulence Factors - genetics ; Virulence Factors - metabolism
Is Part Of: Science (American Association for the Advancement of Science), 2004-12, Vol.306 (5703), p.1934-1937
Description: Malaria parasites secrete proteins across the vacuolar membrane into the erythrocyte, inducing modifications linked to disease and parasite survival. We identified an 11-amino acid signal required for the secretion of proteins from the Plasmodium falciparum vacuole to the human erythrocyte. Bioinformatics predicted a secretome of >320 proteins and conservation of the signal across parasite species. Functional studies indicated the predictive value of the signal and its role in targeting virulence proteins to the erythrocyte and implicated its recognition by a receptor/transporter. Erythrocyte modification by the parasite may involve plasmodial heat shock proteins and be vastly more complex than hitherto realized.
Publisher: Washington, DC: American Association for the Advancement of Science
Language: English
Identifier: ISSN: 0036-8075
EISSN: 1095-9203
DOI: 10.1126/science.1102737
PMID: 15591203
CODEN: SCIEAS
Source: MEDLINE
ProQuest Central

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A Host-Targeting Signal in Virulence Proteins Reveals a Secretome in Malarial Infection

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