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Elevated C-reactive protein and pro-inflammatory cytokines in Andean women with pre-eclampsia

International journal of gynecology and obstetrics, 2001-12, Vol.75 (3), p.243-249 [Peer Reviewed Journal]

2001 International Federation of Gynecology and Obstetrics ;2002 INIST-CNRS ;ISSN: 0020-7292 ;EISSN: 1879-3479 ;DOI: 10.1016/S0020-7292(01)00499-4 ;PMID: 11728484 ;CODEN: IJGOAL

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Title:
Elevated C-reactive protein and pro-inflammatory cytokines in Andean women with pre-eclampsia
Author: Teran, E. ; Escudero, C. ; Moya, W. ; Flores, M. ; Vallance, P. ; Lopez-Jaramillo, P.
Subjects: Adult ; Analysis of Variance ; Biological and medical sciences ; Blood Pressure ; C-reactive protein ; C-Reactive Protein - analysis ; Cross-Sectional Studies ; Cytokines ; Diseases of mother, fetus and pregnancy ; Ecuador ; Enzyme-Linked Immunosorbent Assay ; Female ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Inflammation ; Interleukin-6 - blood ; Leukocyte Count ; Medical sciences ; Parity ; Pre-eclampsia ; Pre-Eclampsia - blood ; Pregnancy ; Pregnancy. Fetus. Placenta ; Tropical medicine ; Tumor Necrosis Factor-alpha - analysis
Is Part Of: International journal of gynecology and obstetrics, 2001-12, Vol.75 (3), p.243-249
Description: Objective: To investigate the concentration of markers of inflammation in non-pregnant women, women with normal pregnancy and women with pre-eclampsia. Methods: Pregnant women ( n=26), women with pre-eclampsia ( n=25) and non-pregnant normotensive women ( n=21) were included in the study. C-reactive protein was measured by latex-enhanced immunoturbidimetric assay, serum tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) by high sensitivity ELISA. Kruskal–Wallis non-parametric analysis of variance followed by the Mann–Whitney U-test were used for statistical analyses. Results: Higher values (mean±S.E.M.) of C-reactive protein were found in pre-eclampsia (4.11±0.37 mg/dl) compared with normal pregnant women (2.49±0.26 mg/dl) and non-pregnant controls (1.33±0.15 mg/dl). TNF-α was significantly higher in women with pre-eclampsia (15.74±5.09 pg/ml), in relation to the control group (2.76±0.41 pg/ml) and women with normal pregnancy (8.31±1.55 pg/ml). IL-6 levels were significantly higher in pre-eclamptic women (12.91±1.29 pg/ml) compared with normal pregnant (5.07±0.423 pg/ml) and control women (1.25±0.13 pg/ml). Conclusions: The results of this cross-sectional study in a high-risk Andean population show that both C-reactive protein and pro-inflammatory cytokines are present in higher concentrations in women with pre-eclampsia. The study was undertaken in women with established pre-eclampsia and it is not possible to determine whether the increased concentrations of C-reactive protein and pro-inflammatory cytokines were a cause or consequence of the disease.
Publisher: Shannon: Elsevier Ireland Ltd
Language: English
Identifier: ISSN: 0020-7292
EISSN: 1879-3479
DOI: 10.1016/S0020-7292(01)00499-4
PMID: 11728484
CODEN: IJGOAL
Source: MEDLINE
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Elevated C-reactive protein and pro-inflammatory cytokines in Andean women with pre-eclampsia

2001 International Federation of Gynecology and Obstetrics ;2002 INIST-CNRS ;ISSN: 0020-7292 ;EISSN: 1879-3479 ;DOI: 10.1016/S0020-7292(01)00499-4 ;PMID: 11728484 ;CODEN: IJGOAL

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