Language:

Dicer is essential for mouse development

Nature genetics, 2003-11, Vol.35 (3), p.215-217 [Peer Reviewed Journal]

2004 INIST-CNRS ;COPYRIGHT 2003 Nature Publishing Group ;ISSN: 1061-4036 ;EISSN: 1546-1718 ;DOI: 10.1038/ng1253 ;PMID: 14528307 ;CODEN: NGENEC

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Dicer is essential for mouse development
Author: Hannon, Gregory J ; Bernstein, Emily ; Kim, Sang Yong ; Carmell, Michelle A ; Murchison, Elizabeth P ; Alcorn, Heather ; Li, Mamie Z ; Mills, Alea A ; Elledge, Stephen J ; Anderson, Kathryn V
Subjects: Amino Acid Sequence ; Animals ; Biological and medical sciences ; Cell differentiation, maturation, development, hematopoiesis ; Cell physiology ; DEAD-box RNA Helicases ; Dicer gene ; Embryo ; Embryonic and Fetal Development - physiology ; Endoribonucleases - genetics ; Endoribonucleases - physiology ; Fundamental and applied biological sciences. Psychology ; Gene silencing ; Genetic aspects ; Methods ; Mice ; Mice, Knockout ; Molecular and cellular biology ; Molecular Sequence Data ; Physiological aspects ; Ribonuclease III ; RNA Helicases - genetics ; RNA Helicases - physiology ; RNA Interference ; Stem Cells - cytology
Is Part Of: Nature genetics, 2003-11, Vol.35 (3), p.215-217
Description: To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.
Publisher: London: Nature Publishing Group
Language: English
Identifier: ISSN: 1061-4036
EISSN: 1546-1718
DOI: 10.1038/ng1253
PMID: 14528307
CODEN: NGENEC
Source: GFMER Free Medical Journals
MEDLINE
ProQuest Central

Back to results list

Previous Result 3 Next Go to Next page


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Dicer is essential for mouse development

2004 INIST-CNRS ;COPYRIGHT 2003 Nature Publishing Group ;ISSN: 1061-4036 ;EISSN: 1546-1718 ;DOI: 10.1038/ng1253 ;PMID: 14528307 ;CODEN: NGENEC

Searching Remote Databases, Please Wait