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Role of Transforming Growth Factor β in Human Disease

The New England journal of medicine, 2000-05, Vol.342 (18), p.1350-1358 [Peer Reviewed Journal]

Copyright © 2000 Massachusetts Medical Society. All rights reserved. ;2000 INIST-CNRS ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJM200005043421807 ;PMID: 10793168 ;CODEN: NEJMAG

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Title:
Role of Transforming Growth Factor β in Human Disease
Author: Blobe, Gerard C ; Schiemann, William P ; Lodish, Harvey F
Epstein, Franklin H.
Subjects: Animals ; Arteriosclerosis - genetics ; Biological and medical sciences ; Cell Cycle - physiology ; Embryonic and Fetal Development - physiology ; Fibrosis - genetics ; Health aspects ; Humans ; Immune Tolerance ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Miscellaneous. Technology ; Neoplasm Metastasis - physiopathology ; Neoplasms - genetics ; Neoplasms - pathology ; Neoplasms - physiopathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Signal Transduction ; Telangiectasia, Hereditary Hemorrhagic - genetics ; Transforming Growth Factor beta - genetics ; Transforming Growth Factor beta - physiology ; Transforming growth factors
Is Part Of: The New England journal of medicine, 2000-05, Vol.342 (18), p.1350-1358
Description: In human tissues, normal homeostasis requires intricately balanced interactions between cells and the network of secreted proteins known as the extracellular matrix. These cooperative interactions involve numerous cytokines acting through specific cell-surface receptors. When the balance between the cells and the extracellular matrix is perturbed, disease can result. This is clearly evident in the interactions mediated by the cytokine transforming growth factor β (TGF-β). TGF-β is a member of a family of dimeric polypeptide growth factors that includes bone morphogenic proteins and activins. All of these growth factors share a cluster of conserved cysteine residues that form a common cysteine . . .
Publisher: Boston, MA: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJM200005043421807
PMID: 10793168
CODEN: NEJMAG
Source: ProQuest One Psychology
MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Role of Transforming Growth Factor β in Human Disease

Copyright © 2000 Massachusetts Medical Society. All rights reserved. ;2000 INIST-CNRS ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJM200005043421807 ;PMID: 10793168 ;CODEN: NEJMAG

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