Language:

Right ventricular mechanics and QRS duration in patients with repaired tetralogy of fallot : Implications of infundibular disease

Circulation (New York, N.Y.), 2007-10, Vol.116 (14), p.1532-1539 [Peer Reviewed Journal]

2007 INIST-CNRS ;ISSN: 0009-7322 ;EISSN: 1524-4539 ;DOI: 10.1161/CIRCULATIONAHA.107.688770 ;PMID: 17875972 ;CODEN: CIRCAZ

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Right ventricular mechanics and QRS duration in patients with repaired tetralogy of fallot : Implications of infundibular disease
Author: UEBING, Anselm ; GIBSON, Derek G ; WEI LI ; BABU-NARAYAN, Sonya V ; DILLER, Gerhard P ; DIMOPOULOS, Konstantinos ; GOKTEKIN, Omer ; SPENCE, Mark S ; ANDERSEN, Kai ; HENEIN, Michael Y ; GATZOULIS, Michael A
Subjects: Adult ; Biological and medical sciences ; Blood and lymphatic vessels ; Bundle-Branch Block - diagnosis ; Bundle-Branch Block - physiopathology ; Bundle-Branch Block - therapy ; Cardiac Pacing, Artificial ; Cardiology. Vascular system ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Echocardiography - standards ; Electrocardiography ; General and cellular metabolism. Vitamins ; Heart Conduction System - physiopathology ; Heart Conduction System - surgery ; Humans ; Magnetic Resonance Imaging - standards ; Medical sciences ; Myocardial Contraction ; Pharmacology. Drug treatments ; Prospective Studies ; Reproducibility of Results ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Tetralogy of Fallot - diagnostic imaging ; Tetralogy of Fallot - physiopathology ; Tetralogy of Fallot - surgery ; Ventricular Function, Right - physiology
Is Part Of: Circulation (New York, N.Y.), 2007-10, Vol.116 (14), p.1532-1539
Description: Patients after repair of tetralogy of Fallot (ToF) frequently have right ventricular (RV) dysfunction and prolonged QRS duration (QRSd) and thus could be candidates for cardiac resynchronization therapy. We aimed to assess the relationship between QRSd and the timing of RV wall motion, including the RV outflow tract (RVOT), in these patients. Sixty-seven repaired ToF patients (median age, 34 years; interquartile range, 24 to 43 years) and 35 age-matched control subjects were studied by echocardiography and cardiovascular magnetic resonance (n=55 of 67 ToF patients). Time intervals of the RV cardiac cycle were measured from Doppler recordings. Long-axis M-mode recordings were acquired from the right ventricular (RV) free wall and RV outflow tract (RVOT), and the delay in onset of long-axis shortening was measured. ToF patients showed minor abnormalities of the RV cardiac cycle unrelated to QRSd. RV ejection time was prolonged and correspondingly filling time was reduced compared with control subjects (22.3+/-2.6 versus 20.0+/-2.9 s/min, P<0.0001; 29.0+/-3.8 versus 32.7+/-3.5 s/min, P<0.0001). Total isovolumic time was normal in ToF patients (8.7+/-4.0 versus 7.4+/-2.9 s/min; P=NS). QRSd correlated with the delay in RV free wall motion (r=0.55, P<0.0001) and more so with the delay in RVOT shortening (r=0.82, P<0.0001). QRSd also correlated with measures of RVOT abnormality such as long-axis RVOT excursion and akinetic area length (r=-0.46, P=0.004; r=0.33, P=0.01). QRSd in postoperative ToF patients reflects mainly abnormalities of the RVOT rather than the RV body itself. Thus, prevention and treatment of mechanical asynchrony and malignant arrhythmia should focus on the RV infundibulum. Indications for cardiac resynchronization therapy after ToF repair warrant further investigation.
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
Language: English
Identifier: ISSN: 0009-7322
EISSN: 1524-4539
DOI: 10.1161/CIRCULATIONAHA.107.688770
PMID: 17875972
CODEN: CIRCAZ
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Right ventricular mechanics and QRS duration in patients with repaired tetralogy of fallot : Implications of infundibular disease

2007 INIST-CNRS ;ISSN: 0009-7322 ;EISSN: 1524-4539 ;DOI: 10.1161/CIRCULATIONAHA.107.688770 ;PMID: 17875972 ;CODEN: CIRCAZ

Searching Remote Databases, Please Wait