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Full-length genomic sequencing and analysis of four HIV type 1 subtype B isolates circulating in the territory of Russia

AIDS research and human retroviruses, 2006-11, Vol.22 (11), p.1192-1197 [Peer Reviewed Journal]

2007 INIST-CNRS ;ISSN: 0889-2229 ;EISSN: 1931-8405 ;DOI: 10.1089/aid.2006.22.1192 ;PMID: 17147510 ;CODEN: ARHRE7

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  • Title:
    Full-length genomic sequencing and analysis of four HIV type 1 subtype B isolates circulating in the territory of Russia
  • Author: GALKIN, Alexander N ; GAGARINA, Ekaterina Y ; LUKYANOVA, Natalia S ; DANILOVA, Tatyana V
  • Subjects: AIDS/HIV ; Female ; Genome, Viral ; HIV Infections - epidemiology ; HIV Infections - virology ; HIV-1 - classification ; HIV-1 - genetics ; HIV-1 - isolation & purification ; Human immunodeficiency virus 1 ; Humans ; Male ; Molecular Sequence Data ; Phylogeny ; Retrovirus ; Russia - epidemiology
  • Is Part Of: AIDS research and human retroviruses, 2006-11, Vol.22 (11), p.1192-1197
  • Description: We describe four full-length genomic sequences of HIV-1 subtype B isolates from Russia. These full-length HIV-1 genomes were amplified by nested polymerase chain reaction and sequenced. The sequences obtained were subjected to neighbor-joining phylogenetic analysis using a Kimura two-parameter model and to detailed sequence analysis. Comparison of the sequences obtained with 68 near full-length HIV-1 subtype B sequences from different geographic regions of the world revealed that isolates from Russia did not cluster significantly with other subtype B genomes. Sequences AY819715 and AY751407 significantly formed one cluster, which indicates their close similarity. The HIV-1 genomes obtained from Russia did not form a distinct homogeneous group inside subtype B. Their genetic diversity probably reflects the result of multiple introduction events of different subtype B strains to Russia. Sequences AY819715 and AY751406 possess some features of viruses from long-term survivors, such as specific extensions of the Env V2 region.
  • Publisher: Larchmont, NY: Liebert
  • Language: Russian;English
  • Identifier: ISSN: 0889-2229
    EISSN: 1931-8405
    DOI: 10.1089/aid.2006.22.1192
    PMID: 17147510
    CODEN: ARHRE7
  • Source: MEDLINE
    Alma/SFX Local Collection
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