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Percutaneous coronary intervention versus conservative therapy in nonacute coronary artery disease : A meta-analysis

Circulation (New York, N.Y.), 2005-06, Vol.111 (22), p.2906-2912 [Peer Reviewed Journal]

2005 INIST-CNRS ;ISSN: 0009-7322 ;EISSN: 1524-4539 ;DOI: 10.1161/CIRCULATIONAHA.104.521864 ;PMID: 15927966 ;CODEN: CIRCAZ

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Title:
Percutaneous coronary intervention versus conservative therapy in nonacute coronary artery disease : A meta-analysis
Author: KATRITSIS, Demosthenes G ; IOANNIDIS, John P. A
Subjects: Angina Pectoris - therapy ; Angioplasty, Balloon, Coronary - adverse effects ; Angioplasty, Balloon, Coronary - statistics & numerical data ; Bayes Theorem ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood. Blood coagulation. Reticuloendothelial system ; Cardiology. Vascular system ; Cardiovascular Agents - therapeutic use ; Coronary Artery Disease - therapy ; Coronary Disease - drug therapy ; Coronary Disease - surgery ; Coronary Disease - therapy ; Coronary heart disease ; Coronary Stenosis - therapy ; Death ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Female ; Heart ; Humans ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction ; Myocardial Revascularization ; Odds Ratio ; Pharmacology. Drug treatments ; Randomized Controlled Trials as Topic ; Risk Assessment ; Treatment Outcome
Is Part Of: Circulation (New York, N.Y.), 2005-06, Vol.111 (22), p.2906-2912
Description: Percutaneous coronary intervention (PCI) has been shown to improve symptoms compared with conservative medical treatment in patients with stable coronary artery disease (CAD); however, there is limited evidence on the effect of PCI on the risk of death, myocardial infarction, and subsequent revascularization. Therefore, we performed a meta-analysis of 11 randomized trials comparing PCI to conservative treatment in patients with stable CAD. A total of 2950 patients were included in the meta-analysis (1476 received PCI, and 1474 received conservative treatment). There was no significant difference between the 2 treatment strategies with regard to mortality, cardiac death or myocardial infarction, nonfatal myocardial infarction, CABG, or PCI during follow-up. By random effects, the risk ratios (95% CIs) for the PCI versus conservative treatment arms were 0.94 (0.72 to 1.24), 1.17 (0.88 to 1.57), 1.28 (0.94 to 1.75), 1.03 (0.80 to 1.33), and 1.23 (0.80 to 1.90) for these 5 outcomes, respectively. A possible survival benefit was seen for PCI only in trials of patients who had a relatively recent myocardial infarction (risk ratio 0.40, 95% CI 0.17 to 0.95). Except for PCI during follow-up, there was no significant between-study heterogeneity for any outcome. In patients with chronic stable CAD, in the absence of a recent myocardial infarction, PCI does not offer any benefit in terms of death, myocardial infarction, or the need for subsequent revascularization compared with conservative medical treatment.
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
Language: English
Identifier: ISSN: 0009-7322
EISSN: 1524-4539
DOI: 10.1161/CIRCULATIONAHA.104.521864
PMID: 15927966
CODEN: CIRCAZ
Source: Geneva Foundation Free Medical Journals at publisher websites
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Percutaneous coronary intervention versus conservative therapy in nonacute coronary artery disease : A meta-analysis

2005 INIST-CNRS ;ISSN: 0009-7322 ;EISSN: 1524-4539 ;DOI: 10.1161/CIRCULATIONAHA.104.521864 ;PMID: 15927966 ;CODEN: CIRCAZ

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