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Hospital-acquired neonatal infections in developing countries

The Lancet (British edition), 2005-03, Vol.365 (9465), p.1175-1188 [Peer Reviewed Journal]

2005 Elsevier Ltd ;2005 INIST-CNRS ;Copyright Lancet Ltd. Mar 26-Apr 1, 2005 ;ISSN: 0140-6736 ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(05)71881-X ;PMID: 15794973 ;CODEN: LANCAO

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Title:
Hospital-acquired neonatal infections in developing countries
Author: Zaidi, Anita KM ; Huskins, W Charles ; Thaver, Durrane ; Bhutta, Zulfiqar A ; Abbas, Zohair ; Goldmann, Donald A
Subjects: Babies ; Biological and medical sciences ; Cross Infection - epidemiology ; Cross Infection - microbiology ; Cross Infection - prevention & control ; Developing countries ; Developing Countries - statistics & numerical data ; Drug Resistance, Bacterial ; General aspects ; Hospitals ; Humans ; Incidence ; Infant Care ; Infant, Newborn ; Infection Control ; Infections ; Klebsiella Infections - epidemiology ; LDCs ; Medical sciences ; Neonatal care ; Risk Factors ; Sepsis - epidemiology ; Sepsis - microbiology
Is Part Of: The Lancet (British edition), 2005-03, Vol.365 (9465), p.1175-1188
Description: Hospital-born babies in developing countries are at increased risk of neonatal infections because of poor intrapartum and postnatal infection-control practices. We reviewed data from developing countries on rates of neonatal infections among hospital-born babies, range of pathogens, antimicrobial resistance, and infection-control interventions. Reported rates of neonatal infections were 3–20 times higher than those reported for hospital-born babies in industrialised countries. Klebsiella pneumoniae, other gram-negative rods ( Escherichia coli, Pseudomonas spp, Acinetobacter spp), and Staphylococcus aureus were the major pathogens among 11 471 bloodstream isolates reported. These infections can often present soon after birth. About 70% would not be covered by an empiric regimen of ampicillin and gentamicin, and many might be untreatable in resource-constrained environments. The associated morbidity, mortality, costs, and adverse effect on future health-seeking behaviour by communities pose barriers to improvement of neonatal outcomes in developing countries. Low-cost, “bundled” interventions using systems quality improvement approaches for improved infection control are possible, but should be supported by evidence in developing country settings.
Publisher: London: Elsevier Ltd
Language: English
Identifier: ISSN: 0140-6736
EISSN: 1474-547X
DOI: 10.1016/S0140-6736(05)71881-X
PMID: 15794973
CODEN: LANCAO
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Hospital-acquired neonatal infections in developing countries

2005 Elsevier Ltd ;2005 INIST-CNRS ;Copyright Lancet Ltd. Mar 26-Apr 1, 2005 ;ISSN: 0140-6736 ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(05)71881-X ;PMID: 15794973 ;CODEN: LANCAO

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