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Poly-immunoglobulin receptor-mediated transport of IgA into the male genital tract is important for clearance of Chlamydia muridarum infection

American journal of reproductive immunology (1989), 2008-11, Vol.60 (5), p.405-414 [Peer Reviewed Journal]

ISSN: 1046-7408 ;EISSN: 1600-0897 ;DOI: 10.1111/j.1600-0897.2008.00637.x ;PMID: 18803626

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Title:
Poly-immunoglobulin receptor-mediated transport of IgA into the male genital tract is important for clearance of Chlamydia muridarum infection
Author: Cunningham, Kelly A ; Carey, Alison J ; Finnie, Jane M ; Bao, Shisan ; Coon, Charmere ; Jones, Russell ; Wijburg, Odilia ; Strugnell, Richard A ; Timms, Peter ; Beagley, Kenneth W
Subjects: Animals ; Antibodies, Bacterial - immunology ; Antibodies, Bacterial - metabolism ; Chlamydia ; Chlamydia Infections - immunology ; Chlamydia muridarum - immunology ; Cytokines - immunology ; Cytokines - metabolism ; Immunoglobulin A - immunology ; Immunoglobulin A - metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Prostate - immunology ; Prostate - microbiology ; Receptors, Polymeric Immunoglobulin - genetics ; Receptors, Polymeric Immunoglobulin - immunology ; Receptors, Polymeric Immunoglobulin - metabolism
Is Part Of: American journal of reproductive immunology (1989), 2008-11, Vol.60 (5), p.405-414
Description: Chlamydia trachomatis is the most common sexually transmitted infection worldwide. While infection in females requires a Th1 response for clearance, such a response in males may disrupt the immune privileged nature of the male reproductive tract, potentially contributing to infertility. We investigated the role of IgA in protection against an intrapenile Chlamydia muridarum infection of C57BL/6 and pIgR-/- mice. Here, we show that the poly immunoglobulin receptor is the main pathway for IgA transport into the male reproductive tract. The high levels of IgA seen in prostatic fluid of wild-type mice correlate with reduction in chlamydial infection both in vitro and in vivo. These findings indicate that a Chlamydia vaccine that induces neutralizing IgA in the prostate will aid in the protection against infection in males.
Publisher: Denmark
Language: English
Identifier: ISSN: 1046-7408
EISSN: 1600-0897
DOI: 10.1111/j.1600-0897.2008.00637.x
PMID: 18803626
Source: MEDLINE
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Poly-immunoglobulin receptor-mediated transport of IgA into the male genital tract is important for clearance of Chlamydia muridarum infection

ISSN: 1046-7408 ;EISSN: 1600-0897 ;DOI: 10.1111/j.1600-0897.2008.00637.x ;PMID: 18803626

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