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A High Fibrosis-4 Index is Associated with a Reduction in the Estimated Glomerular Filtration Rate in Non-obese Japanese Patients with Type 2 Diabetes Mellitus

Kobe journal of the medical sciences, 2024-04, Vol.70 (1), p.E39-E45 [Peer Reviewed Journal]

EISSN: 1883-0498 ;DOI: 10.24546/0100489395 ;PMID: 38719339

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Title:
A High Fibrosis-4 Index is Associated with a Reduction in the Estimated Glomerular Filtration Rate in Non-obese Japanese Patients with Type 2 Diabetes Mellitus
Author: Inoue, Hiroyuki ; Asahara, Shun-Ichiro ; Nakamura, Fumihiko ; Kido, Yoshiaki
Subjects: Aged ; Body Mass Index ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - physiopathology ; East Asian People ; Female ; Glomerular Filtration Rate ; Humans ; Japan ; Liver Cirrhosis - complications ; Liver Cirrhosis - physiopathology ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease - complications ; Non-alcoholic Fatty Liver Disease - physiopathology ; Obesity - complications ; Obesity - physiopathology ; Risk Factors ; Severity of Illness Index
Is Part Of: Kobe journal of the medical sciences, 2024-04, Vol.70 (1), p.E39-E45
Description: Liver fibrosis is associated with non-alcoholic fatty liver disease (NAFLD), and one of the most important risk factors for NAFLD is type 2 diabetes (T2DM). The Fibrosis-4 (FIB-4) index, a noninvasive liver fibrosis score, has been found to be useful for estimating liver fibrosis. Because individuals with non-obese NAFLD were recently reported to be metabolically unhealthy and have a higher risk of T2DM than individuals with obese NAFLD, we hypothesized that the clinical factors related to a high FIB-4 index would differ between non-obese and obese Japanese T2DM patients. Accordingly, we examined the relationship between clinical factors and the FIB-4 index in non-obese and obese Japanese patients with T2DM. We divided 265 patients into two groups by BMI level - a non-obese group (n = 149) and an obese group (n = 116) - and examined the correlation between the FIB-4 index and clinical parameters. Single regression analysis revealed that a high FIB-4 index was correlated with a reduction in the estimated glomerular filtration rate and hypertension in the non-obese group. Importantly, multiple regression analysis showed that only a reduction in the estimated glomerular filtration rate was significantly associated with a high FIB-4 index in the non-obese group. These results demonstrated that non-obese T2DM patients with a high FIB-4 index might be at risk of kidney dysfunction. Our findings may enable the more appropriate treatment of T2DM patients based on BMI level.
Publisher: Japan
Language: English
Identifier: EISSN: 1883-0498
DOI: 10.24546/0100489395
PMID: 38719339
Source: Freely Accessible Japanese Titles (ERDB Project)
GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection

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A High Fibrosis-4 Index is Associated with a Reduction in the Estimated Glomerular Filtration Rate in Non-obese Japanese Patients with Type 2 Diabetes Mellitus

EISSN: 1883-0498 ;DOI: 10.24546/0100489395 ;PMID: 38719339

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