skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Antimicrobial use related problems and determinants in surgical ward of Ethiopian tertiary hospital

PloS one, 2023-12, Vol.18 (12), p.e0296284-e0296284 [Peer Reviewed Journal]

Copyright: © 2023 Niriayo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ;COPYRIGHT 2023 Public Library of Science ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0296284 ;PMID: 38134131

Full text available

Citations Cited by
  • Title:
    Antimicrobial use related problems and determinants in surgical ward of Ethiopian tertiary hospital
  • Author: Niriayo, Yirga Legesse ; Ayalneh, Melisew ; Demoz, Gebre Teklemariam ; Tesfay, Nigusse ; Gidey, Kidu
  • Shankar, Pathiyil Ravi
  • Subjects: Anti-Bacterial Agents - therapeutic use ; Anti-infective agents ; Antibiotic Prophylaxis ; Antibiotics ; Care and treatment ; Cloxacillin ; Communicable diseases ; Dosage and administration ; Ethiopia ; Ethiopia - epidemiology ; Health aspects ; Hospital patients ; Hospital wards ; Hospitalization ; Hospitals, Special ; Humans ; Medical care, Cost of ; Metronidazole ; Mortality ; Patient outcomes ; Pharmacists ; Safety and security measures ; Surgeons ; Tertiary Care Centers ; World health
  • Is Part Of: PloS one, 2023-12, Vol.18 (12), p.e0296284-e0296284
  • Description: Antibiotic use related problems lead to the emergence of resistance, failure of therapy, morbidity, mortality, and unnecessary healthcare expenditure. However, little is known about antimicrobial use related problems in our setting particularly in hospitalized surgical patients. The purpose of this study was to investigate antibiotic use related problems and their determinants among hospitalized surgical patients. A prospective observational study was conducted from December 2018 to April 2019 at the surgical ward of the Ayder comprehensive specialized hospital, located in Northern Ethiopia. We included patients admitted to the surgical ward who were on antibiotic therapy or were candidates for antibiotic therapy/prophylaxis. The patients were recruited during admission and were followed daily until discharge. Data were collected through patient interviews and expert reviews of medical and medication records. The appropriateness of antibiotic use was evaluated according to the Infectious Disease Society of America, American Society of Health System Pharmacists, and World Health Organization guidelines. Subsequently, antibiotic use related problems were identified and classified based on Cipolle's method followed by consensus review with experts. Binary logistic regression was performed to identify the determinants of antibiotic use related problems. Statistical significance was set at p <0.05. Among 272 patients, 167(61.4%) experienced antibiotics use related problems. A total of 235 antibiotics use related problems were identified equating 0.86Ā±0.82 problems per patient. The commonly identified antibiotic use related problems were the need for additional drug therapy (29.4%), unnecessary drug therapy (15%), and dosage too high (12.1%). Cephalosporin (47.02%) was the most commonly implicated class of antibiotics in these drug related problems, followed by penicillin (18.45%) and metronidazole (16.02%). Prolonged hospitalization (AOR: 3.57, 95% CI: 1.91-6.70), number of medicationsā‰„5 (AOR: 2.08, 95%CI: 1.10-3.94), and lower qualifications of practitioners [general practitioners (AOR: 10.27, 95%CI: 4.13-25.58) and surgical residents (AOR: 2.28, 95%CI: 1.12-4.63)] were predictors of antibiotic use related problems. Antibiotic use related problems were common among the hospitalized surgical patients. Prolonged hospitalizations, number of medications, and lower qualifications of practitioners were predictors of antibiotic use related problems. Therefore, more emphasis should be given for patients with prolonged hospitalization and multiple medications. Moreover, practitioners with higher qualifications including surgical specialists need to be involved in patient evaluations.
  • Publisher: United States: Public Library of Science
  • Language: English
  • Identifier: ISSN: 1932-6203
    EISSN: 1932-6203
    DOI: 10.1371/journal.pone.0296284
    PMID: 38134131
  • Source: Public Library of Science (PLoS) Journals Open Access
    Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    PubMed Central
    Directory of Open Access Journals
    ProQuest Central
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait