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The prognostic impact of peritoneal tumour DNA in gastrointestinal and gynaecological malignancies: a systematic review

British journal of cancer, 2023-11, Vol.129 (11), p.1717-1726 [Peer Reviewed Journal]

2023. The Author(s), under exclusive licence to Springer Nature Limited. ;The Author(s), under exclusive licence to Springer Nature Limited 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. ;ISSN: 0007-0920 ;EISSN: 1532-1827 ;DOI: 10.1038/s41416-023-02424-6 ;PMID: 37700064

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Title:
The prognostic impact of peritoneal tumour DNA in gastrointestinal and gynaecological malignancies: a systematic review
Author: Allan, Zexi ; Witts, Sasha ; Tie, Jeanne ; Tebbutt, Niall ; Clemons, Nicholas J ; Liu, David S
Subjects: Biopsy ; Cancer ; Cytology ; DNA ; Female ; Genital Neoplasms, Female - diagnosis ; Genital Neoplasms, Female - genetics ; Genital Neoplasms, Female - pathology ; Gynecology ; Humans ; Laparoscopy ; Malignancy ; Medical prognosis ; Metastases ; Metastasis ; Neoplasm Staging ; Peritoneal diseases ; Peritoneal Diseases - pathology ; Peritoneal Neoplasms - diagnosis ; Peritoneal Neoplasms - genetics ; Peritoneal Neoplasms - pathology ; Peritoneum ; Peritoneum - pathology ; Prognosis ; Stomach cancer ; Stomach Neoplasms - pathology ; Systematic review ; Tumors
Is Part Of: British journal of cancer, 2023-11, Vol.129 (11), p.1717-1726
Description: Peritoneal metastases from various abdominal cancer types are common and carry poor prognosis. The presence of peritoneal disease upstages cancer diagnosis and alters disease trajectory and treatment pathway in many cancer types. Therefore, accurate and timely detection of peritoneal disease is crucial. The current practice of diagnostic laparoscopy and peritoneal lavage cytology (PLC) in detecting peritoneal disease has variable sensitivity. The significant proportion of peritoneal recurrence seen during follow-up in patients where initial PLC was negative indicates the ongoing need for a better diagnostic tool for detecting clinically occult peritoneal disease, especially peritoneal micro-metastases. Advancement in liquid biopsy has allowed the development and use of peritoneal tumour DNA (ptDNA) as a cancer-specific biomarker within the peritoneum, and the presence of ptDNA may be a surrogate marker for early peritoneal metastases. A growing body of literature on ptDNA in different cancer types portends promising results. Here, we conduct a systematic review to evaluate the prognostic impact of ptDNA in various cancer types and discuss its potential future clinical applications, with a focus on gastrointestinal and gynaecological malignancies.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 0007-0920
EISSN: 1532-1827
DOI: 10.1038/s41416-023-02424-6
PMID: 37700064
Source: Geneva Foundation Free Medical Journals at publisher websites
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The prognostic impact of peritoneal tumour DNA in gastrointestinal and gynaecological malignancies: a systematic review

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