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Improved Outcomes After Pulmonary Valve Replacement in Repaired Tetralogy of Fallot

Journal of the American College of Cardiology, 2023-05, Vol.81 (21), p.2075-2085 [Peer Reviewed Journal]

2023 The Authors ;Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved. ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2023.02.052 ;PMID: 37225360

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Title:
Improved Outcomes After Pulmonary Valve Replacement in Repaired Tetralogy of Fallot
Author: Bokma, Jouke P. ; Geva, Tal ; Sleeper, Lynn A. ; Lee, Ji Hae ; Lu, Minmin ; Sompolinsky, Tehila ; Babu-Narayan, Sonya V. ; Wald, Rachel M. ; Mulder, Barbara J.M. ; Valente, Anne Marie
Subjects: Adolescent ; Adult ; Cardiac Surgical Procedures ; cardiovascular magnetic resonance imaging ; congenital heart disease ; Humans ; Propensity Score ; Pulmonary Valve - surgery ; pulmonary valve replacement ; Registries ; Tachycardia, Ventricular - epidemiology ; Tachycardia, Ventricular - etiology ; Tachycardia, Ventricular - surgery ; tetralogy of Fallot ; Tetralogy of Fallot - surgery ; Young Adult
Is Part Of: Journal of the American College of Cardiology, 2023-05, Vol.81 (21), p.2075-2085
Description: The impact of pulmonary valve replacement (PVR) on major adverse clinical outcomes in patients with repaired tetralogy of Fallot (rTOF) is unknown. The purpose of this study was to determine whether PVR is associated with improved survival and freedom from sustained ventricular tachycardia (VT) in rTOF. A PVR propensity score was created to adjust for baseline differences between PVR and non-PVR patients enrolled in INDICATOR (International Multicenter TOF Registry). The primary outcome was time to the earliest occurrence of death or sustained VT. PVR and non-PVR patients were matched 1:1 on PVR propensity score (matched cohort) and in the full cohort, modeling was performed with propensity score as a covariate adjustment. Among 1,143 patients with rTOF (age 27 ± 14 years, 47% PVR, follow-up 8.3 ± 5.2 years), the primary outcome occurred in 82. The adjusted HR for the primary outcome for PVR vs no-PVR (matched cohort n = 524) was 0.41 (95% CI: 0.21-0.81; multivariable model P = 0.010). Full cohort analysis revealed similar results. Subgroup analysis suggested beneficial effects in patients with advanced right ventricular (RV) dilatation (interaction P = 0.046; full cohort). In patients with RV end-systolic volume index >80 mL/m2, PVR was associated with a lower primary outcome risk (HR: 0.32; 95% CI: 0.16-0.62; P < 0.001). There was no association between PVR and the primary outcome in patients with RV end-systolic volume index ≤80 mL/m2 (HR: 0.86; 95% CI: 0.38-1.92; P = 0.70). Compared with rTOF patients who did not receive PVR, propensity score-matched individuals receiving PVR had lower risk of a composite endpoint of death or sustained VT. [Display omitted]
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0735-1097
EISSN: 1558-3597
DOI: 10.1016/j.jacc.2023.02.052
PMID: 37225360
Source: GFMER Free Medical Journals
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Improved Outcomes After Pulmonary Valve Replacement in Repaired Tetralogy of Fallot

2023 The Authors ;Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved. ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2023.02.052 ;PMID: 37225360

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