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Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome

Nature genetics, 2022-01, Vol.54 (1), p.52-61 [Peer Reviewed Journal]

2022. The Author(s), under exclusive licence to Springer Nature America, Inc. ;ISSN: 1061-4036 ;EISSN: 1546-1718 ;DOI: 10.1038/s41588-021-00968-y ;PMID: 34980918

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Title:
Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome
Author: Liu, Xiaomin ; Tong, Xin ; Zou, Yuanqiang ; Lin, Xiaoqian ; Zhao, Hui ; Tian, Liu ; Jie, Zhuye ; Wang, Qi ; Zhang, Zhe ; Lu, Haorong ; Xiao, Liang ; Qiu, Xuemei ; Zi, Jin ; Wang, Rong ; Xu, Xun ; Yang, Huanming ; Wang, Jian ; Zong, Yang ; Liu, Weibin ; Hou, Yong ; Zhu, Shida ; Jia, Huijue ; Zhang, Tao
Subjects: Blood - metabolism ; Cohort Studies ; Feces - microbiology ; Gastrointestinal Microbiome - genetics ; Genetic Variation ; Genome-Wide Association Study ; Glutamic Acid - blood ; Humans ; Mendelian Randomization Analysis ; Metagenome ; Triglycerides - blood
Is Part Of: Nature genetics, 2022-01, Vol.54 (1), p.52-61
Description: The gut microbiome has been implicated in a variety of physiological states, but controversy over causality remains unresolved. Here, we performed bidirectional Mendelian randomization analyses on 3,432 Chinese individuals with whole-genome, whole-metagenome, anthropometric and blood metabolic trait data. We identified 58 causal relationships between the gut microbiome and blood metabolites, and replicated 43 of them. Increased relative abundances of fecal Oscillibacter and Alistipes were causally linked to decreased triglyceride concentration. Conversely, blood metabolites such as glutamic acid appeared to decrease fecal Oxalobacter, and members of Proteobacteria were influenced by metabolites such as 5-methyltetrahydrofolic acid, alanine, glutamate and selenium. Two-sample Mendelian randomization with data from Biobank Japan partly corroborated results with triglyceride and with uric acid, and also provided causal support for published fecal bacterial markers for cancer and cardiovascular diseases. This study illustrates the value of human genetic information to help prioritize gut microbial features for mechanistic and clinical studies.
Publisher: United States
Language: English
Identifier: ISSN: 1061-4036
EISSN: 1546-1718
DOI: 10.1038/s41588-021-00968-y
PMID: 34980918
Source: Geneva Foundation Free Medical Journals at publisher websites
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ProQuest Central

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Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome

2022. The Author(s), under exclusive licence to Springer Nature America, Inc. ;ISSN: 1061-4036 ;EISSN: 1546-1718 ;DOI: 10.1038/s41588-021-00968-y ;PMID: 34980918

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