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Platelet Total PLA2 Activity, Serum Oxidative Level, and Plasma Cu/Zn Ratio: A Vicious Cycle with a Potential Role to Monitor MCI and Alzheimer's Disease Progression

Rejuvenation research, 2022-02, Vol.25 (1), p.16-24 [Peer Reviewed Journal]

2022, Mary Ann Liebert, Inc., publishers ;ISSN: 1549-1684 ;EISSN: 1557-8577 ;DOI: 10.1089/rej.2021.0020

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  • Title:
    Platelet Total PLA2 Activity, Serum Oxidative Level, and Plasma Cu/Zn Ratio: A Vicious Cycle with a Potential Role to Monitor MCI and Alzheimer's Disease Progression
  • Author: Balietti, Marta ; Casoli, Tiziana ; Giacconi, Robertina ; Giuli, Cinzia
  • Subjects: Original Articles
  • Is Part Of: Rejuvenation research, 2022-02, Vol.25 (1), p.16-24
  • Description: Alzheimer's disease (AD) has no cure, mainly because of late diagnosis. Early diagnostic biomarkers are crucial. Phospholipases A 2 (PLA 2 ) are hydrolases with several functions in the brain, nevertheless their deregulation contributes to neurodegeneration. We evaluated platelet total PLA 2 activity (p tot PLA 2 ) in healthy elderly subjects (HE, n  = 102), patients suffering from mild cognitive impairment (MCI, n  = 90) and AD ( n  = 91). Platelets are considered “circulating neurons” and p tot PLA 2 appears to mirror the cerebral activity. p tot PLA 2 of the three cohorts was similar, but in MCI the higher p tot PLA 2 the worse the global cognitive status (Mini Mental State Examination score [MMSE]) and in AD the lower p tot PLA 2 the more severe the pathology stage (Clinical Dementia Rating [CDR]). Accordingly, MCI with MMSE ≥26 overlapped HE, in MCI with MMSE <26 and in AD with CDR 1 p tot PLA 2 increased, in AD with CDR 2 p tot PLA 2 decreased. In MCI p tot PLA 2 positively correlated with blood oxidation and inflammation, in AD it was the opposite. Finally, Discrimination Index (DI)—calculated multiplying p tot PLA 2 , oxidative level and Cu/Zn ratio (an inflammation parameter)—differentiated MCI patients who progressed to dementia in the following 24 months and AD patients with the worse pathology development. Summarizing, p tot PLA 2 changes during MCI and AD progression, is linked, in opposite way, to oxidative/inflammatory status in MCI and AD and might help, when included in DI, to identify MCI converters to dementia and AD patients with the more severe prognosis. p tot PLA 2 may have a diagnostic/prognostic value and be a potential therapeutic target.
  • Publisher: Mary Ann Liebert, Inc., publishers
  • Language: English
  • Identifier: ISSN: 1549-1684
    EISSN: 1557-8577
    DOI: 10.1089/rej.2021.0020
  • Source: Alma/SFX Local Collection
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