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Pars Plana Vitrectomy with Internal Limiting Membrane Peeling for Treatment-Naïve Diabetic Macular Edema: A Prospective, Uncontrolled Pilot Study

Clinical ophthalmology (Auckland, N.Z.), 2021, Vol.15, p.2619-2624

ISSN: 1177-5467 ;EISSN: 1177-5483 ;DOI: 10.2147/OPTH.S320214

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  • Title:
    Pars Plana Vitrectomy with Internal Limiting Membrane Peeling for Treatment-Naïve Diabetic Macular Edema: A Prospective, Uncontrolled Pilot Study
  • Author: Rush, Ryan B ; Rush, Sloan W
  • Is Part Of: Clinical ophthalmology (Auckland, N.Z.), 2021, Vol.15, p.2619-2624
  • Description: PURPOSETo report the outcomes in subjects undergoing pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling for the management of treatment-naïve diabetic macular edema (DME). METHODSTen treatment-naïve subjects with non-proliferative diabetic retinopathy prospectively underwent PPV with ILM peeling for the treatment of DME at a single university-affiliated institution. The preoperative features, intraoperative details and postoperative outcomes were collected and analyzed. RESULTSAll 10 subjects underwent PPV with ILM peeling without significant intraoperative or postoperative complications at 6 months follow-up. Visual acuity improved from a baseline of 0.74 (95% CI: 0.48-1.0) logMAR (Snellen 20/110) to 0.46 (95% CI: 0.3-0.62) logMAR (Snellen 20/58) at 6 months follow-up (p=0.045). Optical coherence tomography central macular thickness reduced from a baseline of 456 (95% CI: 394.7-516.4) microns to 316.8 (95% CI: 275.9-357.7) microns at 6 months follow-up (p < 0.001). CONCLUSIONThis pilot study suggests that PPV with ILM peeling may be a viable treatment option for the management of treatment naïve DME in subjects with non-proliferative diabetic retinopathy. Development of a randomized controlled trial may be justified to validate the results of this study. CLINICALTRIALSGOV IDENTIFIER #NCT03660345.
  • Language: English
  • Identifier: ISSN: 1177-5467
    EISSN: 1177-5483
    DOI: 10.2147/OPTH.S320214
  • Source: Geneva Foundation Free Medical Journals
    PubMed Central (Open access)
    AUTh Library subscriptions: ProQuest Central
    DOAJ Directory of Open Access Journals
    Dove Press Free
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