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Purely organic light-harvesting phosphorescence energy transfer by β-cyclodextrin pseudorotaxane for mitochondria targeted imaging

Chemical science (Cambridge), 2020-12, Vol.12 (5), p.1851-1857 [Peer Reviewed Journal]

This journal is © The Royal Society of Chemistry. ;Copyright Royal Society of Chemistry 2021 ;This journal is © The Royal Society of Chemistry 2021 The Royal Society of Chemistry ;ISSN: 2041-6520 ;EISSN: 2041-6539 ;DOI: 10.1039/d0sc05343k ;PMID: 34163949

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  • Title:
    Purely organic light-harvesting phosphorescence energy transfer by β-cyclodextrin pseudorotaxane for mitochondria targeted imaging
  • Author: Shen, Fang-Fang ; Chen, Yong ; Dai, Xianyin ; Zhang, Hao-Yang ; Zhang, Bing ; Liu, Yaohua ; Liu, Yu
  • Subjects: Aqueous solutions ; Assembly ; Cancer ; Chemistry ; Cyclodextrins ; Energy harvesting ; Energy transfer ; Fluorescence ; Hyaluronic acid ; Imaging ; Mitochondria ; Nanoparticles ; Phosphorescence ; Positron emission ; Rhodamine ; Tomography
  • Is Part Of: Chemical science (Cambridge), 2020-12, Vol.12 (5), p.1851-1857
  • Description: A new type of purely organic light-harvesting phosphorescence energy transfer (PET) supramolecular assembly is constructed from 4-(4-bromophenyl)-pyridine modified β-cyclodextrin (CD-PY) as a donor, cucurbit[8]uril (CB[8]) as a mediator, rhodamine B (RhB) as an acceptor, and adamantane modified hyaluronic acid (HA-ADA) as a cancer cell targeting agent. Interestingly, the complexation of free CD-PY, which has no RTP emission in aqueous solution, with CB[8] results in the formation of CD-PY@CB[8] pseudorotaxane with an RTP emission at 510 nm. Then the addition of RhB leads to an efficient light-harvesting PET process with highly efficient energy transfer and an ultrahigh antenna effect (36.42) between CD-PY@CB[8] pseudorotaxane and RhB. Importantly, CD-PY@CB[8]@RhB assembles with HA-ADA into nanoparticles with further enhanced delayed emission at 590 nm. The nanoparticles could be successfully used for mitochondria targeted imaging in A549 cancer cells. This aqueous-state PET based on a supramolecular assembly strategy has potential application in delayed fluorescence cell imaging. A new type of purely organic light-harvesting PET supramolecular assembly is constructed with efficient energy transfer and ultrahigh antenna effect. Moreover, the assembly could be used for mitochondria targeted imaging in A549 cancer cells.
  • Publisher: England: Royal Society of Chemistry
  • Language: English
  • Identifier: ISSN: 2041-6520
    EISSN: 2041-6539
    DOI: 10.1039/d0sc05343k
    PMID: 34163949
  • Source: PubMed Central
    DOAJ Directory of Open Access Journals
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