skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

High-dimensional characterization of post-acute sequelae of COVID-19

Nature (London), 2021-06, Vol.594 (7862), p.259-264 [Peer Reviewed Journal]

COPYRIGHT 2021 Nature Publishing Group ;Copyright Nature Publishing Group Jun 10, 2021 ;ISSN: 0028-0836 ;EISSN: 1476-4687 ;DOI: 10.1038/s41586-021-03553-9 ;PMID: 33887749

Full text available

Citations Cited by
  • Title:
    High-dimensional characterization of post-acute sequelae of COVID-19
  • Author: Al-Aly, Ziyad ; Xie, Yan ; Bowe, Benjamin
  • Subjects: Abnormalities ; Anemia ; Antidepressants ; Antihypertensives ; Chemical compounds ; Cognition ; Complications ; Confidence intervals ; Coronaviruses ; COVID-19 ; Gastrointestinal tract diseases ; Hemoglobin ; Hospitalization ; Laboratories ; Mental disorders ; Mental health ; Metabolic disorders ; Narcotics ; Nervous system ; Opioids ; Pain ; Pharmacology ; Respiratory system ; Severe acute respiratory syndrome coronavirus 2 ; Tumors ; Viral diseases
  • Is Part Of: Nature (London), 2021-06, Vol.594 (7862), p.259-264
  • Description: The acute clinical manifestations of COVID-19 have been well characterized , but the post-acute sequelae of this disease have not been comprehensively described. Here we use the national healthcare databases of the US Department of Veterans Affairs to systematically and comprehensively identify 6-month incident sequelae-including diagnoses, medication use and laboratory abnormalities-in patients with COVID-19 who survived for at least 30 days after diagnosis. We show that beyond the first 30 days of illness, people with COVID-19 exhibit a higher risk of death and use of health resources. Our high-dimensional approach identifies incident sequelae in the respiratory system, as well as several other sequelae that include nervous system and neurocognitive disorders, mental health disorders, metabolic disorders, cardiovascular disorders, gastrointestinal disorders, malaise, fatigue, musculoskeletal pain and anaemia. We show increased incident use of several therapeutic agents-including pain medications (opioids and non-opioids) as well as antidepressant, anxiolytic, antihypertensive and oral hypoglycaemic agents-as well as evidence of laboratory abnormalities in several organ systems. Our analysis of an array of prespecified outcomes reveals a risk gradient that increases according to the severity of the acute COVID-19 infection (that is, whether patients were not hospitalized, hospitalized or admitted to intensive care). Our findings show that a substantial burden of health loss that spans pulmonary and several extrapulmonary organ systems is experienced by patients who survive after the acute phase of COVID-19. These results will help to inform health system planning and the development of multidisciplinary care strategies to reduce chronic health loss among individuals with COVID-19.
  • Publisher: England: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 0028-0836
    EISSN: 1476-4687
    DOI: 10.1038/s41586-021-03553-9
    PMID: 33887749
  • Source: ProQuest One Psychology
    ProQuest Central
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait