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Recapitulating macro-scale tissue self-organization through organoid bioprinting

Nature materials, 2021-01, Vol.20 (1), p.22-29 [Peer Reviewed Journal]

The Author(s), under exclusive licence to Springer Nature Limited 2020. ;ISSN: 1476-1122 ;EISSN: 1476-4660 ;DOI: 10.1038/s41563-020-00803-5 ;PMID: 32958879

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Title:
Recapitulating macro-scale tissue self-organization through organoid bioprinting
Author: Brassard, Jonathan A ; Nikolaev, Mike ; Hübscher, Tania ; Hofer, Moritz ; Lutolf, Matthias P
Subjects: Bioprinting - methods ; Computer architecture ; Crypts ; Extracellular Matrix - metabolism ; Gastrointestinal system ; Gastrointestinal Tract - cytology ; Lumens ; Morphogenesis ; Organoids - metabolism ; Regeneration (physiology) ; Regenerative medicine ; Stem cells ; Three dimensional printing ; Tissue engineering ; Vascular tissue
Is Part Of: Nature materials, 2021-01, Vol.20 (1), p.22-29
Description: Bioprinting promises enormous control over the spatial deposition of cells in three dimensions , but current approaches have had limited success at reproducing the intricate micro-architecture, cell-type diversity and function of native tissues formed through cellular self-organization. We introduce a three-dimensional bioprinting concept that uses organoid-forming stem cells as building blocks that can be deposited directly into extracellular matrices conducive to spontaneous self-organization. By controlling the geometry and cellular density, we generated centimetre-scale tissues that comprise self-organized features such as lumens, branched vasculature and tubular intestinal epithelia with in vivo-like crypts and villus domains. Supporting cells were deposited to modulate morphogenesis in space and time, and different epithelial cells were printed sequentially to mimic the organ boundaries present in the gastrointestinal tract. We thus show how biofabrication and organoid technology can be merged to control tissue self-organization from millimetre to centimetre scales, opening new avenues for drug discovery, diagnostics and regenerative medicine.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1476-1122
EISSN: 1476-4660
DOI: 10.1038/s41563-020-00803-5
PMID: 32958879
Source: MEDLINE
ProQuest Central

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Recapitulating macro-scale tissue self-organization through organoid bioprinting

The Author(s), under exclusive licence to Springer Nature Limited 2020. ;ISSN: 1476-1122 ;EISSN: 1476-4660 ;DOI: 10.1038/s41563-020-00803-5 ;PMID: 32958879

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