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Evaluation of the Choroid in Eyes With Retinitis Pigmentosa and Cystoid Macular Edema

Investigative ophthalmology & visual science, 2019-12, Vol.60 (15), p.5000-5006 [Peer Reviewed Journal]

ISSN: 1552-5783 ;EISSN: 1552-5783 ;DOI: 10.1167/iovs.19-27300 ;PMID: 31794599

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  • Title:
    Evaluation of the Choroid in Eyes With Retinitis Pigmentosa and Cystoid Macular Edema
  • Author: Iovino, Claudio ; Au, Adrian ; Hilely, Assaf ; Violanti, Sara ; Peiretti, Enrico ; Gorin, Michael B ; Sarraf, David
  • Subjects: Choroid - pathology ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Humans ; Macular Edema - diagnosis ; Male ; Middle Aged ; Retina - pathology ; Retinitis Pigmentosa - diagnosis ; Retrospective Studies ; Severity of Illness Index ; Tomography, Optical Coherence - methods ; Visual Acuity
  • Is Part Of: Investigative ophthalmology & visual science, 2019-12, Vol.60 (15), p.5000-5006
  • Description: To study the anatomical choroidal features associated with the presence of cystoid macular edema (CME) in eyes with retinitis pigmentosa (RP). A total of 159 eyes (from 159 patients) with a diagnosis of RP were enrolled in this retrospective cross-sectional case-control study and divided into two groups based on the presence (67 eyes) or absence (92 eyes) of CME. Retinal and choroidal features were evaluated on spectral domain optical coherence tomography including central macular thickness (CMT) and subfoveal choroidal thickness (CT). Total choroidal area (TCA), choroidal luminal area (LA), and choroidal stromal area (SA) were measured and the choroidal vascularity index (CVI) was calculated in all study eyes. Average age was 49.2 ± 14.9 and 47.1 ± 15.5 years (P = 0.40) and logMAR Snellen visual acuity (VA) was 0.4 ± 0.6 (median 0.3, 20/40) and 0.2 ± 0.4 (median 0.1, 20/25) in the RP groups with and without CME, respectively (P = 0.05). Mean CMT was 334.1 ± 93.5 and 252.6 ± 47.6 μm in the RP groups with and without CME, respectively (P < 0.001). The subfoveal CT was significantly increased in the RP group with versus without CME (294.2 ± 110.9 μm vs. 198.1 ± 75.5 μm, respectively, P < 0.001). In patients with CME, the CVI was lower (P < 0.001) and the TCA, LA, and SA were all significantly higher (P < 0.001). In patients with CME associated with RP, the choroid exhibited significantly greater subfoveal thickening and decreased CVI. The choroid may be an important factor to consider in the etiology of CME in patients with RP.
  • Publisher: United States
  • Language: English
  • Identifier: ISSN: 1552-5783
    EISSN: 1552-5783
    DOI: 10.1167/iovs.19-27300
    PMID: 31794599
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    PubMed Central
    Alma/SFX Local Collection
    DOAJ: Directory of Open Access Journals
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