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Mechanisms of atrial fibrillation

Heart (British Cardiac Society), 2019-12, Vol.105 (24), p.1860-1867 [Peer Reviewed Journal]

Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. ;2019 Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. ;ISSN: 1355-6037 ;EISSN: 1468-201X ;DOI: 10.1136/heartjnl-2018-314267 ;PMID: 31444267

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Title:
Mechanisms of atrial fibrillation
Author: Wijesurendra, Rohan S ; Casadei, Barbara
Subjects: Atrial Fibrillation - diagnostic imaging ; Atrial Fibrillation - etiology ; Atrial Fibrillation - genetics ; Atrial Fibrillation - physiopathology ; Atrial Remodeling - physiology ; Cardiac arrhythmia ; Catheters ; Circuits ; Electrophysiological Phenomena - physiology ; Genetic Predisposition to Disease ; Heart Atria - diagnostic imaging ; Heart Atria - physiopathology ; Heart attacks ; Humans ; Hypotheses ; Magnetic Resonance Imaging - methods ; Oxidation-Reduction
Is Part Of: Heart (British Cardiac Society), 2019-12, Vol.105 (24), p.1860-1867
Description: Atrial fibrillation (AF) is the most common sustained arrhythmia, currently affecting over 33 million individuals worldwide, and its prevalence is expected to more than double over the next 40 years. AF is associated with a twofold increase in premature mortality, and important major adverse cardiovascular events such as heart failure, severe stroke and myocardial infarction. Significant effort has been made over a number of years to define the underlying cellular, molecular and electrophysiological changes that predispose to the induction and maintenance of AF in patients. Progress has been limited by the realisation that AF is a complex arrhythmia that can be the end result of various different pathophysiological processes, with significant heterogeneity between individual patients (and between species). In this focused Review article, we aim to succinctly summarise for the non-specialist the current state of knowledge regarding the mechanisms of AF. We address all aspects of pathophysiology, including the basic electrophysiological and structural changes within the left atrium, the genetics of AF and the links to comorbidities and wider systemic and metabolic perturbations that may be upstream contributors to development of AF. Finally, we outline the translational implications for current and future rhythm control strategies in patients with AF.
Publisher: England: BMJ Publishing Group LTD
Language: English
Identifier: ISSN: 1355-6037
EISSN: 1468-201X
DOI: 10.1136/heartjnl-2018-314267
PMID: 31444267
Source: MEDLINE
ProQuest Central

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Mechanisms of atrial fibrillation

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