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Antibiotic development - economic, regulatory and societal challenges
Nature reviews. Microbiology, 2020-05, Vol.18 (5), p.267-274
[Peer Reviewed Journal]
Springer Nature Limited 2019. ;ISSN: 1740-1526 ;EISSN: 1740-1534 ;DOI: 10.1038/s41579-019-0293-3 ;PMID: 31745330
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Title:
Antibiotic development - economic, regulatory and societal challenges
Author:
Årdal, Christine
;
Balasegaram, Manica
;
Laxminarayan, Ramanan
;
McAdams, David
;
Outterson, Kevin
;
Rex, John H
;
Sumpradit, Nithima
Subjects:
Anti-Bacterial Agents - isolation & purification
;
Anti-Bacterial Agents - pharmacology
;
Antibiotic resistance
;
Antibiotics
;
Bacteria - drug effects
;
Biotechnology
;
Drug Development - economics
;
Drug Development - organization & administration
;
Drug Development - trends
;
Drug discovery
;
Drug Discovery - economics
;
Drug Discovery - organization & administration
;
Drug Discovery - trends
;
Drug Resistance, Bacterial
;
Drying
;
Economics
;
Feasibility
;
Global Health
;
Health Policy
;
Humans
;
Motivation
;
Pharmaceutical industry
;
Public health
;
R&D
;
Regulators
;
Research & development
Is Part Of:
Nature reviews. Microbiology, 2020-05, Vol.18 (5), p.267-274
Description:
Antibiotic resistance is undoubtedly one of the greatest challenges to global health, and the emergence of resistance has outpaced the development of new antibiotics. However, investments by the pharmaceutical industry and biotechnology companies for research into and development of new antibiotics are diminishing. The public health implications of a drying antibiotic pipeline are recognized by policymakers, regulators and many companies. In this Viewpoint article, seven experts discuss the challenges that are contributing to the decline in antibiotic drug discovery and development, and the national and international initiatives aimed at incentivizing research and the development of new antibiotics to improve the economic feasibility of antibiotic development. In this Viewpoint article, seven experts discuss the challenges that are contributing to the decline in antibiotic drug discovery and development, and the international and national initiatives aimed at incentivizing research and the development of new antibiotics to improve the economic feasibility of antibiotic development.
Publisher:
England: Nature Publishing Group
Language:
English
Identifier:
ISSN: 1740-1526
EISSN: 1740-1534
DOI: 10.1038/s41579-019-0293-3
PMID: 31745330
Source:
MEDLINE
ProQuest Central
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