Ngôn ngữ:

Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management

Cellular and molecular life sciences : CMLS, 2020, Vol.77 (1), p.93-113 [Tạp chí có phản biện]

Springer Nature Switzerland AG 2019 ;Cellular and Molecular Life Sciences is a copyright of Springer, (2019). All Rights Reserved. ;ISSN: 1420-682X ;EISSN: 1420-9071 ;DOI: 10.1007/s00018-019-03253-8 ;PMID: 31377843

Tài liệu số/Tài liệu điện tử

Trích dẫn Trích dẫn bởi

Gửi đến

Nhan đề:
Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management
Tác giả: Barati, Erfaneh ; Nikzad, Hossein ; Karimian, Mohammad
Chủ đề: Animals ; Antioxidants ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Capacitation ; Cell Biology ; Deactivation ; Deoxyribonucleic acid ; Disease control ; Disease Management ; DNA ; DNA damage ; Enzymes ; Epigenetic inheritance ; Epigenetics ; Gene mutations ; Global health ; Hormones ; Hormones, Sex ; Humans ; Inactivation ; Infertility ; Infertility, Male ; Infertility, Male - drug therapy ; Infertility, Male - metabolism ; Infertility, Male - physiopathology ; Inflammation ; Levels ; Life Sciences ; Lipid peroxidation ; Lipids ; Male ; Men ; Mutation ; Oxidation ; Oxidative stress ; Oxidative Stress - drug effects ; Peroxidation ; Physiological aspects ; Physiological effects ; Physiology ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Review ; Semen ; Sex hormones ; Side effects ; Sperm ; Spermatozoa ; Spermatozoa - drug effects ; Spermatozoa - metabolism ; Spermatozoa - pathology ; World health
Là 1 phần của: Cellular and molecular life sciences : CMLS, 2020, Vol.77 (1), p.93-113
Mô tả: Infertility is a global health problem involving about 15% of couples. Approximately half of the infertility cases are related to male factors. The oxidative stress, which refers to an imbalance in levels of reactive oxygen species (ROS) and antioxidants, is one of the main causes of infertility in men. A small amount of ROS is necessary for the physiological function of sperm including the capacitation, hyperactivation and acrosomal reaction. However, high levels of ROS can cause infertility through not only by lipid peroxidation or DNA damage but inactivation of enzymes and oxidation of proteins in spermatozoa. Oxidative stress (OS) is mainly caused by factors associated with lifestyle. Besides, immature spermatozoa, inflammatory factors, genetic mutations and altering levels of sex hormones are other main source of ROS. Since OS occurs due to the lack of antioxidants and its side effects in semen, lifestyle changes and antioxidant regimens can be helpful therapeutic approaches to overcome this problem. The present study aimed to describe physiological ROS production, roles of genetic and epigenetic factors on the OS and male infertility with various mechanisms such as lipid peroxidation, DNA damage, and disorder of male hormone profile, inflammation, and varicocele. Finally, the roles of oral antioxidants and herbs were explained in coping with OS in male infertility.
Nơi xuất bản: Cham: Springer International Publishing
Ngôn ngữ: English
Số nhận dạng: ISSN: 1420-682X
EISSN: 1420-9071
DOI: 10.1007/s00018-019-03253-8
PMID: 31377843
Nguồn: MEDLINE
ProQuest Central

Trở lại danh sách kết quả

Trước Kết quả 20 Tiếp theo Tới trang tiếp theo


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management

Springer Nature Switzerland AG 2019 ;Cellular and Molecular Life Sciences is a copyright of Springer, (2019). All Rights Reserved. ;ISSN: 1420-682X ;EISSN: 1420-9071 ;DOI: 10.1007/s00018-019-03253-8 ;PMID: 31377843

Đang tìm Cơ sở dữ liệu bên ngoài...