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Estrus-Cycle Regulation of Cortical Inhibition

Current biology, 2019-02, Vol.29 (4), p.605-615.e6 [Peer Reviewed Journal]

2019 Elsevier Ltd ;Copyright © 2019 Elsevier Ltd. All rights reserved. ;ISSN: 0960-9822 ;EISSN: 1879-0445 ;DOI: 10.1016/j.cub.2019.01.045 ;PMID: 30744972

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  • Title:
    Estrus-Cycle Regulation of Cortical Inhibition
  • Author: Clemens, Ann M. ; Lenschow, Constanze ; Beed, Prateep ; Li, Lanxiang ; Sammons, Rosanna ; Naumann, Robert K. ; Wang, Hong ; Schmitz, Dietmar ; Brecht, Michael
  • Subjects: Animals ; cortex ; Estrous Cycle - physiology ; estrus ; Female ; inhibition ; interneurons ; Interneurons - physiology ; Neural Inhibition - physiology ; Ovariectomy ; parvalbumin ; Parvalbumins - metabolism ; rat ; Rats ; Rats, Sprague-Dawley ; Rats, Transgenic ; Rats, Wistar ; social touch ; Somatosensory Cortex - physiology ; Touch Perception - physiology
  • Is Part Of: Current biology, 2019-02, Vol.29 (4), p.605-615.e6
  • Description: Female mammals experience cyclical changes in sexual receptivity known as the estrus cycle. Little is known about how estrus affects the cortex, although alterations in sensation, cognition and the cyclical occurrence of epilepsy suggest brain-wide processing changes. We performed in vivo juxtacellular and whole-cell recordings in somatosensory cortex of female rats and found that the estrus cycle potently altered cortical inhibition. Fast-spiking interneurons were strongly activated with social facial touch and varied their ongoing activity with the estrus cycle and estradiol in ovariectomized females, while regular-spiking excitatory neurons did not change. In situ hybridization for estrogen receptor β (Esr2) showed co-localization with parvalbumin-positive (PV+) interneurons in deep cortical layers, mirroring the laminar distribution of our physiological findings. The fraction of neurons positive for estrogen receptor β (Esr2) and PV co-localization (Esr2+PV+) in cortical layer V was increased in proestrus. In vivo and in vitro experiments confirmed that estrogen acts locally to increase fast-spiking interneuron excitability through an estrogen-receptor-β-dependent mechanism. [Display omitted] •Fast-spiking interneurons are strongly activated with social facial touch in rats•Fast-spiking neuron firing is regulated by the estrus cycle and estrogen•Esr2 is expressed in cortical parvalbumin neurons and is regulated by estrus•Excitability of PV neurons is mediated by an estrogen receptor β (Esr2) mechanism Clemens et al. perform in vivo and in vitro electrophysiology in barrel cortex of female rats. Fast-spiking neurons are strongly activated with social touch and vary their firing with the estrus cycle and estradiol. Estrogen acts locally to increase cortical fast-spiking neuron excitability with an estrogen receptor β (Esr2) mechanism.
  • Publisher: England: Elsevier Ltd
  • Language: English
  • Identifier: ISSN: 0960-9822
    EISSN: 1879-0445
    DOI: 10.1016/j.cub.2019.01.045
    PMID: 30744972
  • Source: Cell Press Free Archives
    MEDLINE
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