Language:

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

Proceedings of the National Academy of Sciences - PNAS, 2009-06, Vol.106 (22), p.9075-9080 [Peer Reviewed Journal]

Copyright 1993-2008 National Academy of Sciences of the United States of America ;Copyright National Academy of Sciences Jun 2, 2009 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.0901507106 ;PMID: 19451647

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli
Author: Cavanaugh, Daniel J ; Lee, Hyosang ; Lo, Liching ; Shields, Shannon D ; Zylka, Mark J ; Basbaum, Allan I ; Anderson, David J
Subjects: Animals ; Behavior ; Behavior, Animal ; Biological Sciences ; Brain - physiology ; Cold Temperature ; Diphtheria Toxin - pharmacology ; Genetics ; Hot Temperature ; Hypersensitivity ; Mechanical threshing ; Mental stimulation ; Mice ; Mice, Mutant Strains ; Nerve Fibers, Unmyelinated - physiology ; Neurons ; Neuropsychology ; Nociceptors ; Pain ; Pain - physiopathology ; Pain sensitivity ; Pharmacology ; Proteins ; Receptors ; Receptors, G-Protein-Coupled - genetics ; Spinal cord ; Stress, Mechanical ; TRPV Cation Channels - antagonists & inhibitors
Is Part Of: Proceedings of the National Academy of Sciences - PNAS, 2009-06, Vol.106 (22), p.9075-9080
Description: Behavioral responses to painful stimuli require peripheral sensory neurons called nociceptors. Electrophysiological studies show that most C-fiber nociceptors are polymodal (i.e., respond to multiple noxious stimulus modalities, such as mechanical and thermal); nevertheless, these stimuli are perceived as distinct. Therefore, it is believed that discrimination among these modalities only occurs at spinal or supraspinal levels of processing. Here, we provide evidence to the contrary. Genetic ablation in adulthood of unmyelinated sensory neurons expressing the G protein-coupled receptor Mrgprd reduces behavioral sensitivity to noxious mechanical stimuli but not to heat or cold stimuli. Conversely, pharmacological ablation of the central branches of TRPV1⁺ nociceptors, which constitute a nonoverlapping population, selectively abolishes noxious heat pain sensitivity. Combined elimination of both populations yielded an additive phenotype with no additional behavioral deficits, ruling out a redundant contribution of these populations to heat and mechanical pain sensitivity. This double-dissociation suggests that the brain can distinguish different noxious stimulus modalities from the earliest stages of sensory processing.
Publisher: United States: National Academy of Sciences
Language: English
Identifier: ISSN: 0027-8424
EISSN: 1091-6490
DOI: 10.1073/pnas.0901507106
PMID: 19451647
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

Copyright 1993-2008 National Academy of Sciences of the United States of America ;Copyright National Academy of Sciences Jun 2, 2009 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.0901507106 ;PMID: 19451647

Searching Remote Databases, Please Wait