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Vascular complications in diabetes: old messages, new thoughts

Diabetologia, 2017-11, Vol.60 (11), p.2129-2138 [Peer Reviewed Journal]

Springer-Verlag GmbH Germany 2017 ;Diabetologia is a copyright of Springer, 2017. ;ISSN: 0012-186X ;EISSN: 1432-0428 ;DOI: 10.1007/s00125-017-4360-x ;PMID: 28725914

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Title:
Vascular complications in diabetes: old messages, new thoughts
Author: Forbes, Josephine M. ; Fotheringham, Amelia K.
Subjects: Cardiovascular Diseases - complications ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - metabolism ; Clinical trials ; Computer applications ; Diabetes ; Diabetes mellitus ; Diabetic Nephropathies - etiology ; Diabetic Nephropathies - genetics ; Diabetic Nephropathies - metabolism ; Diabetic Neuropathies - etiology ; Diabetic Neuropathies - genetics ; Diabetic Neuropathies - metabolism ; Diabetic Retinopathy - etiology ; Diabetic Retinopathy - genetics ; Diabetic Retinopathy - metabolism ; Epigenetics ; Human Physiology ; Humans ; Internal Medicine ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Mitochondria ; Pandemics ; Reactive oxygen species ; Review
Is Part Of: Diabetologia, 2017-11, Vol.60 (11), p.2129-2138
Description: In parallel with the growing diabetes pandemic, there is an increasing burden of micro- and macrovascular complications, occurring in the majority of patients. The identification of a number of synergistic accelerators of disease, providing therapeutic pathways, has stabilised the incidence of complications in most western nations. However, the primary instigators of diabetic complications and, thus, prevention strategies, remain elusive. This has necessitated a refocus on natural history studies, where tissue and plasma samples are sequentially taken to determine when and how disease initiates. In addition, recent Phase III trials, wherein the pleiotropic effects of compounds were arguably as beneficial as their glucose-lowering capacity in slowing the progression of complications, have identified knowledge gaps. Recently the influence of other widely recognised pathological pathways, such as mitochondrial production of reactive oxygen species, has been challenged, highlighting the need for a diverse and robust global research effort to ascertain viable therapeutic targets. Technological advances, such as -omics, high-resolution imaging and computational modelling, are providing opportunities for strengthening and re-evaluating research findings. Newer areas such as epigenetics, energetics and the increasing scrutiny of our synergistic inhabitants, the microbiota, also offer novel targets as biomarkers. Ultimately, however, this field requires concerted lobbying to support all facets of diabetes research.
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
Language: English
Identifier: ISSN: 0012-186X
EISSN: 1432-0428
DOI: 10.1007/s00125-017-4360-x
PMID: 28725914
Source: MEDLINE
ProQuest Central

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Vascular complications in diabetes: old messages, new thoughts

Springer-Verlag GmbH Germany 2017 ;Diabetologia is a copyright of Springer, 2017. ;ISSN: 0012-186X ;EISSN: 1432-0428 ;DOI: 10.1007/s00125-017-4360-x ;PMID: 28725914

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