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Common genetic polymorphisms in the promoter of resistin gene are major determinants of plasma resistin concentrations in humans

Diabetologia, 2004-03, Vol.47 (3), p.559-565 [Peer Reviewed Journal]

2004 INIST-CNRS ;Copyright Springer-Verlag 2004 ;ISSN: 0012-186X ;EISSN: 1432-0428 ;DOI: 10.1007/s00125-003-1319-x ;PMID: 14740159

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Title:
Common genetic polymorphisms in the promoter of resistin gene are major determinants of plasma resistin concentrations in humans
Author: CHO, Y. M ; YOUN, B.-S ; CHUNG, S. S ; KIM, K. W ; LEE, H. K ; YU, K.-Y ; PARK, H. J ; SHIN, H. D ; PARK, K. S
Subjects: Aged ; Biological and medical sciences ; Diabetes Mellitus, Type 2 - genetics ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Gene Frequency ; Genotype ; Haplotypes - genetics ; Hormones, Ectopic - blood ; Hormones, Ectopic - genetics ; Humans ; Korea ; Male ; Medical sciences ; Middle Aged ; Polymorphism, Genetic - genetics ; Polymorphism, Single Nucleotide - genetics ; Promoter Regions, Genetic - genetics ; Reference Values ; Resistin
Is Part Of: Diabetologia, 2004-03, Vol.47 (3), p.559-565
Description: Resistin is thought to be an important link between obesity and insulin resistance. It has been suggested that genetic polymorphism in the promoter of resistin gene is a determinant of resistin mRNA expression and possibly associated with obesity and insulin resistance. In this study, we investigated the association between the genotype of resistin promoter and its plasma concentrations. We examined g.-537A>C and g.-420C>G polymorphisms in the resistin promoter and measured plasma resistin concentrations in Korean subjects with or without Type 2 diabetes. We also did haplotype-based promoter activity assays and the gel electrophoretic mobility shift assay. The -420G and the -537A alleles, which were in linkage disequilibrium, were associated with higher plasma resistin concentrations. Individuals with haplotype A-G (-537A and -420G) had significantly higher plasma resistin concentrations than the others. Haplotype A-G had modestly increased promoter activity compared to the other haplotypes. Electrophoretic mobility shift assay showed that the -420G allele is specific for binding of nuclear proteins from adipocytes and monocytes. However, none of the two polymorphisms were associated with Type 2 diabetes or obesity in our study subjects. Polymorphisms in the promoter of resistin gene are major determinants of plasma resistin concentrations in humans.
Publisher: Berlin: Springer
Language: English
Identifier: ISSN: 0012-186X
EISSN: 1432-0428
DOI: 10.1007/s00125-003-1319-x
PMID: 14740159
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Common genetic polymorphisms in the promoter of resistin gene are major determinants of plasma resistin concentrations in humans

2004 INIST-CNRS ;Copyright Springer-Verlag 2004 ;ISSN: 0012-186X ;EISSN: 1432-0428 ;DOI: 10.1007/s00125-003-1319-x ;PMID: 14740159

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