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Insulin resistance and chronic inflammation

Postȩpy higieny i medycyny doświadczalnej, 2016-12, Vol.70, p.1245-1258 [Peer Reviewed Journal]

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Title:
Insulin resistance and chronic inflammation
Author: Matulewicz, Natalia ; Karczewska-Kupczewska, Monika
Subjects: Adipose Tissue - metabolism ; Animals ; Humans ; Inflammation - metabolism ; Inflammation Mediators - metabolism ; Insulin Resistance - physiology ; Oxidative Stress - physiology ; Receptor, Insulin - metabolism
Is Part Of: Postȩpy higieny i medycyny doświadczalnej, 2016-12, Vol.70, p.1245-1258
Description: Insulin resistance is a condition of reduced biological response to insulin. Growing evidence indicates the role of the chronic low-grade inflammatory response in the pathogenesis of insulin resistance. Adipose tissue in obesity is characterized by increased lipolysis with the excessive release of free fatty acids, and is also a source of proinflammatory cytokines. Both these factors may inhibit insulin action. Proinflammatory cytokines exert their effect by stimulating major inflammatory NFκB and JNK pathways within the cells. Inflammatory processes in other insulin responsive tissues may also play a role in inducing insulin resistance. This paper is an overview of the chronic low-grade inflammation in adipose tissue, skeletal muscle, liver and endothelial cells during the development of insulin resistance.
Publisher: Poland
Language: English
Identifier: EISSN: 1732-2693
PMID: 28026827
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
Alma/SFX Local Collection

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