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Assessing the Role of Ih Channels in Synaptic Transmission and Mossy Fiber LTP

Proceedings of the National Academy of Sciences - PNAS, 2002-07, Vol.99 (14), p.9538-9543 [Peer Reviewed Journal]

Copyright 1993-2002 National Academy of Sciences of the United States of America ;Copyright National Academy of Sciences Jul 9, 2002 ;Copyright © 2002, The National Academy of Sciences 2002 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.142213199 ;PMID: 12093909

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Title:
Assessing the Role of Ih Channels in Synaptic Transmission and Mossy Fiber LTP
Author: Chevaleyre, Vivien ; Castillo, Pablo E.
Subjects: Animals ; Biological Sciences ; Brain ; Cerebellum - physiology ; Cyclic AMP - physiology ; Cyclic Nucleotide-Gated Cation Channels ; Hippocampus ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels ; In Vitro Techniques ; Ion Channels - physiology ; Ions ; Long term potentiation ; Long-Term Potentiation - physiology ; Mossy Fibers, Hippocampal - physiology ; Nerve Fibers - physiology ; Nerve Tissue Proteins - physiology ; Neurology ; Neurons ; Neuroscience ; Potassium Channels ; Purkinje cells ; Radio transmitters ; Rats ; Rats, Sprague-Dawley ; Synapses ; Synaptic transmission ; Synaptic Transmission - physiology ; Tetanus
Is Part Of: Proceedings of the National Academy of Sciences - PNAS, 2002-07, Vol.99 (14), p.9538-9543
Description: Hyperpolarization-activated nonselective cation channels (Ih channels) play an important role in the control of membrane excitability and rhythmic neuronal activity. The functional relevance of presynaptic Ih channels in regulating synaptic function, however, is not well established. Recently, it has been proposed [Mellor, J., Nicoll, R. A. & Schmitz, D. (2002) Science 295, 143-147] that presynaptic Ih channels are necessary for hippocampal mossy fiber long-term potentiation (LTP). This observation challenges an alternative model that suggests presynaptic forms of LTP are caused by a direct modification of the transmitter release machinery. Here, we assess the role of Ih in hippocampal mossy fiber LTP as well as cerebellar parallel fiber LTP, forms of potentiation that share common mechanisms. Our results show that after Ih blockade neither mossy fiber LTP nor parallel fiber LTP are affected. Furthermore, Ih does not significantly modify basal excitatory synaptic transmission in the hippocampus, whereas the organic Ih blockers ZD7288 and DK-AH 269 induce a large Ih-independent depression of synaptic transmission. In summary, our results indicate that Ih-mediated persistent changes in presynaptic excitability do not underlie presynaptic forms of LTP.
Publisher: United States: National Academy of Sciences
Language: English
Identifier: ISSN: 0027-8424
EISSN: 1091-6490
DOI: 10.1073/pnas.142213199
PMID: 12093909
Source: PubMed Central (Open access)
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE

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Assessing the Role of Ih Channels in Synaptic Transmission and Mossy Fiber LTP

Copyright 1993-2002 National Academy of Sciences of the United States of America ;Copyright National Academy of Sciences Jul 9, 2002 ;Copyright © 2002, The National Academy of Sciences 2002 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.142213199 ;PMID: 12093909

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