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Pulmonary macrophages: key players in the innate defence of the airways

Thorax, 2015-12, Vol.70 (12), p.1189-1196 [Peer Reviewed Journal]

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing ;Copyright: 2015 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing ;ISSN: 0040-6376 ;EISSN: 1468-3296 ;DOI: 10.1136/thoraxjnl-2015-207020 ;PMID: 26286722 ;CODEN: THORA7

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Title:
Pulmonary macrophages: key players in the innate defence of the airways
Author: Byrne, Adam J ; Mathie, Sara A ; Gregory, Lisa G ; Lloyd, Clare M
Subjects: Animals ; Asthma - immunology ; Cystic Fibrosis - immunology ; Humans ; Immunity, Innate - immunology ; Immunity, Innate - physiology ; Lung Diseases - immunology ; Macrophages, Alveolar - immunology ; Phenotype ; Pulmonary Disease, Chronic Obstructive - immunology ; Pulmonary Fibrosis - immunology ; Respiratory Tract Infections - immunology
Is Part Of: Thorax, 2015-12, Vol.70 (12), p.1189-1196
Description: Macrophages are the most numerous immune-cells present in the lung environment under homoeostatic conditions and are ideally positioned to dictate the innate defence of the airways. Pulmonary macrophage populations are heterogeneous and demonstrate remarkable plasticity, owing to variations in origin, tissue residency and environmental influences. Lung macrophage diversity facilitates considerable specialisation, aids efficient responses to environmental signals and allows rapid alterations in phenotype and physiology in response to a plethora of cytokines and microbial signals. This review describes pulmonary macrophage origins, phenotypes, roles in diseases of the airways and implications for the treatment of respiratory disease.
Publisher: England: BMJ Publishing Group LTD
Language: English
Identifier: ISSN: 0040-6376
EISSN: 1468-3296
DOI: 10.1136/thoraxjnl-2015-207020
PMID: 26286722
CODEN: THORA7
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Pulmonary macrophages: key players in the innate defence of the airways

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