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Genetic diversity of HPV16 and HPV18 in Brazilian patients with invasive cervical cancer

Journal of medical virology, 2016-07, Vol.88 (7), p.1279-1287 [Peer Reviewed Journal]

2016 Wiley Periodicals, Inc. ;ISSN: 0146-6615 ;EISSN: 1096-9071 ;DOI: 10.1002/jmv.24458 ;PMID: 26694554

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Title:
Genetic diversity of HPV16 and HPV18 in Brazilian patients with invasive cervical cancer
Author: Vidal, Joao Paulo C.B. ; Felix, Shayany Pinto ; Chaves, Cláudia B.P. ; Patury, Patrícia ; Franco, Vanessa F. ; de Morais, Evaneide A. ; de Carvalho, Neile A. ; Carvalho, Aurenice C.L. ; Almeida Neto, Olimpio F. ; Vieira, Lina Maria T.M. ; Correa, Flavia Miranda ; Martins, Luís Felipe Leite ; Negrão, Antonio ; de Almeida, Liz Maria ; Moreira, Miguel Angelo Martins
Subjects: Adult ; Aged ; Brazil - epidemiology ; Cervical cancer ; DNA, Viral - genetics ; DNA-Binding Proteins - genetics ; Female ; Genetic diversity ; Genetic Variation ; Genome, Viral ; Genotype ; HPV genetic diversity ; HPV lineages ; Human papillomavirus ; Human papillomavirus 16 ; Human papillomavirus 16 - genetics ; Human papillomavirus 16 - isolation & purification ; Human papillomavirus 18 ; Human papillomavirus 18 - classification ; Human papillomavirus 18 - genetics ; Human papillomavirus 18 - isolation & purification ; human papillomavirus type 16 ; human papillomavirus type 18 ; Humans ; Middle Aged ; Neoplasm Invasiveness ; Oncogene Proteins, Viral - genetics ; Phylogeny ; Prevalence ; Repressor Proteins - genetics ; Risk Factors ; Uterine Cervical Neoplasms - epidemiology ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - virology ; Virology ; Young Adult
Is Part Of: Journal of medical virology, 2016-07, Vol.88 (7), p.1279-1287
Description: Cervical cancer is the fourth most common cancer among women, and ∼70–80% of these cancers are associated with two human papillomavirus types: HPV16 and HPV18. Several studies have reported that intra‐type diversity is associated with the progression of infection to invasive cancer. Herein, we report the genetic diversity of HPV16 and HPV18 in a cohort of 594 Brazilian women with invasive cervical cancer and describe the prevalence of lineages and intra‐type diversity prior to the implementation of the public immunization program in Brazil. HPV detection and genotyping were performed using PCR, PGMY/GP primers, and DNA extracted from fresh tumors. The HPV16 (378 women) and HPV18 (80 women) lineages were identified by PCR and sequencing of the LCR and E6 fragments, followed by SNV comparison and phylogenetic analysis. In our cohort, was found a higher frequency of the lineage A (in 217 women), followed by lineage D (in 97 women) and lineages B and C (in 10 women each) for HPV16; and a higher frequency of lineage A (in 56 women) followed by lineage B (in 15 women) in HPV18. The genetic diversity of HPV16 indicated a recent expansion of specific variants or a selective advantage that is associated with invasive cancer; this pattern was not observed for HPV18. J. Med. Virol. 88:1279–1287, 2016. © 2015 Wiley Periodicals, Inc.
Publisher: United States: Blackwell Publishing Ltd
Language: English
Identifier: ISSN: 0146-6615
EISSN: 1096-9071
DOI: 10.1002/jmv.24458
PMID: 26694554
Source: MEDLINE
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Genetic diversity of HPV16 and HPV18 in Brazilian patients with invasive cervical cancer

2016 Wiley Periodicals, Inc. ;ISSN: 0146-6615 ;EISSN: 1096-9071 ;DOI: 10.1002/jmv.24458 ;PMID: 26694554

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