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Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction

Circulation research, 2016-01, Vol.118 (2), p.216-221 [Tạp chí có phản biện]

2016 American Heart Association, Inc. ;2015 American Heart Association, Inc. ;ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/CIRCRESAHA.115.307017 ;PMID: 26659640

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Nhan đề:
Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction
Tác giả: Haubner, Bernhard J ; Schneider, Johanna ; Schweigmann, Ulrich ; Schuetz, Thomas ; Dichtl, Wolfgang ; Velik-Salchner, Corinna ; Stein, Joerg-I ; Penninger, Josef M
Chủ đề: Biomarkers - blood ; Cell Death ; Coronary Angiography ; Coronary Occlusion - blood ; Coronary Occlusion - diagnosis ; Coronary Occlusion - physiopathology ; Coronary Occlusion - therapy ; Echocardiography, Doppler, Color ; Electrocardiography ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases - blood ; Infant, Newborn, Diseases - diagnosis ; Infant, Newborn, Diseases - physiopathology ; Infant, Newborn, Diseases - therapy ; Male ; Myocardial Infarction - blood ; Myocardial Infarction - diagnosis ; Myocardial Infarction - physiopathology ; Myocardial Infarction - therapy ; Myocardium - metabolism ; Myocardium - pathology ; Recovery of Function ; Regeneration ; Severity of Illness Index ; Time Factors
Là 1 phần của: Circulation research, 2016-01, Vol.118 (2), p.216-221
Mô tả: RATIONALE:Cardiac remodeling and subsequent heart failure remain critical issues after myocardial infarction despite improved treatment and reperfusion strategies. Recently, cardiac regeneration has been demonstrated in fish and newborn mice after apex resection or cardiac infarctions. Two key issues remain to translate findings in model organisms to future therapies in humanswhat is the mechanism and can cardiac regeneration indeed occur in newborn humans? OBJECTIVE:To assess whether human neonatal hearts can functionally recover after myocardial infarction. METHODS AND RESULTS:Here, we report the case of a newborn child having a severe myocardial infarction due to coronary artery occlusion. The child developed massive cardiac damage as defined by serum markers for cardiomyocyte cell death, electrocardiograms, echocardiography, and cardiac angiography. Remarkably, within weeks after the initial ischemic insult, we observed functional cardiac recovery, which translated into long-term normal heart function. CONCLUSIONS:These data indicate that, similar to neonatal rodents, newborn humans might have the intrinsic capacity to repair myocardial damage and completely recover cardiac function.
Nơi xuất bản: United States: American Heart Association, Inc
Ngôn ngữ: English
Số nhận dạng: ISSN: 0009-7330
EISSN: 1524-4571
DOI: 10.1161/CIRCRESAHA.115.307017
PMID: 26659640
Nguồn: Geneva Foundation Free Medical Journals at publisher websites
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Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction

2016 American Heart Association, Inc. ;2015 American Heart Association, Inc. ;ISSN: 0009-7330 ;EISSN: 1524-4571 ;DOI: 10.1161/CIRCRESAHA.115.307017 ;PMID: 26659640

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