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Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease: A Scientific Statement From the American Heart Association

Circulation (New York, N.Y.), 2015-09, Vol.132 (10), p.965-986 [Peer Reviewed Journal]

2015 American Heart Association, Inc. ;ISSN: 0009-7322 ;EISSN: 1524-4539 ;DOI: 10.1161/CIR.0000000000000229 ;PMID: 26260736

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Title:
Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease: A Scientific Statement From the American Heart Association
Author: Goldstein, Benjamin I ; Carnethon, Mercedes R ; Matthews, Karen A ; McIntyre, Roger S ; Miller, Gregory E ; Raghuveer, Geetha ; Stoney, Catherine M ; Wasiak, Hank ; McCrindle, Brian W
Subjects: Adolescent ; Age Factors ; American Heart Association ; Atherosclerosis - diagnosis ; Atherosclerosis - epidemiology ; Atherosclerosis - psychology ; Bipolar Disorder - diagnosis ; Bipolar Disorder - epidemiology ; Bipolar Disorder - psychology ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - psychology ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - epidemiology ; Depressive Disorder, Major - psychology ; Disease Progression ; Disease Susceptibility ; Humans ; Hypertension - complications ; Hypertension - epidemiology ; Practice Guidelines as Topic - standards ; Risk Factors ; Smoking - adverse effects ; Smoking - epidemiology ; United States - epidemiology
Is Part Of: Circulation (New York, N.Y.), 2015-09, Vol.132 (10), p.965-986
Description: In the 2011 "Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents," several medical conditions among youth were identified that predispose to accelerated atherosclerosis and early cardiovascular disease (CVD), and risk stratification and management strategies for youth with these conditions were elaborated. Major depressive disorder (MDD) and bipolar disorder (BD) among youth satisfy the criteria set for, and therefore merit inclusion among, Expert Panel tier II moderate-risk conditions. The combined prevalence of MDD and BD among adolescents in the United States is ≈10%, at least 10 times greater than the prevalence of the existing moderate-risk conditions combined. The high prevalence of MDD and BD underscores the importance of positioning these diseases alongside other pediatric diseases previously identified as moderate risk for CVD. The overall objective of this statement is to increase awareness and recognition of MDD and BD among youth as moderate-risk conditions for early CVD. To achieve this objective, the primary specific aims of this statement are to (1) summarize evidence that MDD and BD are tier II moderate-risk conditions associated with accelerated atherosclerosis and early CVD and (2) position MDD and BD as tier II moderate-risk conditions that require the application of risk stratification and management strategies in accordance with Expert Panel recommendations. In this scientific statement, there is an integration of the various factors that putatively underlie the association of MDD and BD with CVD, including pathophysiological mechanisms, traditional CVD risk factors, behavioral and environmental factors, and psychiatric medications.
Publisher: United States
Language: English
Identifier: ISSN: 0009-7322
EISSN: 1524-4539
DOI: 10.1161/CIR.0000000000000229
PMID: 26260736
Source: Geneva Foundation Free Medical Journals at publisher websites
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Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease: A Scientific Statement From the American Heart Association

2015 American Heart Association, Inc. ;ISSN: 0009-7322 ;EISSN: 1524-4539 ;DOI: 10.1161/CIR.0000000000000229 ;PMID: 26260736

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